Search Results - TherapeuticArea+%3e+Opthamology

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Photoactivatable Lipid-based Nanoparticles as a Vehicle for Dual Agent Delivery

Abstract: The invention relates to novel lipid-based nanoparticles (liposomes) for use in targeted, on demand and on site drug delivery. The particles include a wall surrounding a cavity, wherein the wall is comprised of: A lipid bilayer comprising 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine...

Published: 4/8/2024 | Inventor(s): Anu Puri, Robert Blumenthal, Amit Joshi, Darayash Tata, Mathias Viard

Keywords(s): Combination Therapy, Delivery Agent, Infections (bacteria and viruses), Lipid nanoparticle, liposome, On-demand Drug Release, photoactivation, therapeutic delivery

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Dermatology, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing, TherapeuticArea > Cardiology

Tissue Clamp for Repeated Opening and Closure of Incisions/Wounds

Abstract: Medical clamps currently available are not efficient nor are they sufficiently precise in closure and alignment of the edges of an incision or wound. Many available designs are difficult to use and handle, especially in situations where repeated opening and closure of an incision or wound is required. The functional short-comings of existing...

Published: 4/8/2024 | Inventor(s): Vladimir Khristov, Steven Charles, Juan Amaral, Arvydas Maminishkis, Kapil Bharti

Keywords(s): CLAMP, ocular surgery, sclera incision closure

Category(s): Collaboration Sought > Collaboration, Application > Non-Medical Devices, Application > Medical Devices, Collaboration Sought > Licensing, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Gene Therapy for Treatment of CRX-Autosomal Dominant Retinopathies

Abstract: Mutations in the cone rod homeobox (CRX) transcription factor lead to distinct retinopathy phenotypes, including early-onset vision impairment in dominant Leber congenital amaurosis (LCA). Adeno-Associated virus (AAV) vector-mediated delivery of a CRX cDNA under the control of a CRX promoter region partially restored photoreceptor phenotype...

Published: 4/8/2024 | Inventor(s): Anand Swaroop, Kamil Kruczek, Suja Hiriyanna, Zhijian Wu

Keywords(s): AAV, Adeno-associated Virus, Cone-rod Dystrophy, CRD, GENE THERAPY, LCA, Leber Congenital Amaurosis, Lentivirus, NEI, rare disease, Retinitis Pigmentosa, Retinopathies, RP, Swaroop

Category(s): TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration

Induced Pluripotent Stem Cells Derived from Patients with CEP290-associated Ciliopathies and Unaffected Family Members

Abstract: Approximately one-third of non-syndromic retinal dystrophies involve a defect in a ciliary protein. Non-syndromic retinal ciliopathies include retinitis pigmentosa, cone dystrophy, cone-rod dystrophy, macular dystrophy, and Leber-congenital amaurosis (LCA). Many CEP290-LCA patients also exhibit auditory and olfactory defects. Induced pluripotent...

Published: 4/8/2024 | Inventor(s): Anand Swaroop, Hiroko Shimada-Ishii, Yu Holly Chen, Milton English

Keywords(s): Anosmia, Cell therapy, Ciliopathies, Congenital Blindness, Drug Development, GENE THERAPY, hearing loss, iPS, National Eye Institute, NEI, Pluripotent Stem Cells, Primary Cilia, Retina, Retinal degeneration, Swaroop, VISION

Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Mouse Embryo Culture Chamber and Imaging System and Methods of Use

Abstract: The culture of mouse embryos ex utero and continuous monitoring and imaging of embryos as they develop have applications in drug testing, genetic studies, and basic research on embryonic development. However, the embryo culture systems currently available for post-implantation embryos include rolling bottle culture systems, which do not permit...

Published: 4/8/2024 | Inventor(s): Vijay Kalaskar

Keywords(s): Culture Chamber, Embryo Development, Embryonic, FETAL, GENE THERAPY, IMAGING, In Vitro Drug Toxicology, Kalaskar, National Eye Institute, NEI, Organ System Therapy

Category(s): Application > Non-Medical Devices, TherapeuticArea > Reproductive Health, Application > Medical Devices, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

New Insect Sf9-ET Cell Line for Determining Baculovirus Titers

Abstract: The baculovirus-based protein expression system has gained increased prominence as a method for expressing recombinant proteins that are used in a wide range of biomedical applications. An important step in the use of this system is the ability to determine the virus infectious titer, i.e., the number of active baculovirus particles produced...

Published: 5/22/2024 | Inventor(s): Ralph (Butch) Hopkins, Dominic Esposito

Keywords(s): Baculovirus, Baculovirus Titer, Esposito, IMMUNE, Inflammation, Insect Cell Line, Protein Expression Sf9-ET

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Collaboration Sought > Licensing, TherapeuticArea > Reproductive Health, TherapeuticArea > Nephrology, Application > Research Materials, TherapeuticArea > Gastroenterology, TherapeuticArea > Endocrinology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Oncology

Strategies to Protect Mammalian Neural Tissue Against Cold and Potentially Other Metabolic Stresses and Physical Damages

Abstract: Researchers at the National Eye Institute (NEI) have discovered an invention describing a composition and method(s) of using such composition for preserving viability of cells, tissues, or organs at a low temperature (around 4ºC). Current cold storage solutions or methods for cells, tissues, and organs are suboptimal due to irreversible...

Published: 4/8/2024 | Inventor(s): Jingxing Ou, Wei Li, Kiyoharu Miyagishima

Keywords(s): Cold Storage, Cold-sensitive, Hypothermia, lysosome, Mitochondria, National Eye Institute, NEI, neural injury, Ou, Protein Degradation, TRANSPLANTATION

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Research Materials, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Nephrology

Surgical Tool for Sub-retinal Tissue Implantation

Abstract: The accurate placement of transplanted tissue at a precise position in the retina is difficult but critical for a successful implementation of an ocular surgical intervention. Researchers at the National Eye Institute (NEI) developed a surgical tool (see image below) designed to place tissue patches, such as sheets of tissue, onto the retina...

Published: 4/8/2024 | Inventor(s): Arvydas Maminishkis

Keywords(s): EYE, Intra-Ocular, Maminishkis, National Eye Institute, NEI, sub-retinal, surgical tool, tissue placement retina

Category(s): Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

A peptide hydrogel for use in vascular anastomosis

Abstract: In collaboration with surgery specialists from Johns Hopkins University, researchers at the National Cancer Institute (NCI) developed novel hydrogel compositions and methods of using them in the microsurgical suturing of blood vessels, which is particularly beneficial for surgeons in whole tissue transplant procedures. The lead candidate electropositive...

Published: 4/8/2024 | Inventor(s): Joel Schneider, Gerald Brandacher, Daniel Smith, Gabriel Brat, Johanna Grahammer

Keywords(s): Anastomosis, Hydrogel, Microsurgery, Peptide, Schneider, Surgery

Bone Marrow Mesenchymal Stem Cell (BMSC)-Derived Exosomes for the Treatment of Glaucoma

Abstract: Glaucoma is one of the world’s leading causes of irreversible blindness. There is no cure and vision lost from glaucoma cannot be restored. Glaucoma is associated with fluid build-up in the eye resulting in an increased intraocular pressure (IOP). The pressure may cause damage to the optic nerve and lead to progressive degeneration of retinal...

Published: 4/8/2024 | Inventor(s): Stanislav Tomarev, Benjamin Mead

Keywords(s): Degenerative Ocular Disease, Exosomes, GLAUCOMA, National Eye Institute, NEI, Neuroprotection, Retinal Ganglion Cell Loss, RGC, Tomarev, Vector Encoding miRNA, Vision Loss

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

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