Search Results - phosphodiesterase

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Phosphodiesterase as a target for cancer therapeutics

Abstract: Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a recently discovered enzyme that catalyzes the hydrolysis of 3'-phosphotyrosyl bonds. Such linkages form in vivo following the DNA processing activity of topoisomerase I (Top1). For this reason, Tdp1 has been implicated in the repair of irreversible Top1-DNA covalent complexes, which can be generated...

Published: 9/11/2024 | Inventor(s): Yves Pommier, Periyasamy Selvam, Christophe Marchand, Thomas Dexheimer, Kasthuraiah Maddali

Keywords(s): Fluoroquinolone, PHOSPHODIESTERASE, Tdp1 inhibitors

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology