Search Results - tyrosyl-dna+phosphodiesterase+2+(tdp)+inhibitors

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Novel Furoquinolinediones as Inhibitors of TDP2 and Their Potential Use to Treat Cancer

Summary: The National Cancer Institute (NCI) seeks licensees for a family of novel furoquinolinedione derivatives that inhibit tyrosyl-DNA phosphodiesterase 2 (TDP2) as cancer therapeutics. Description of Technology: Tyrosyl-DNA phosphodiesterase 2 (TDP2) is an enzyme that plays a critical role in repairing nucleic acid lesions, namely by repairing...

Published: 1/12/2026 | Inventor(s): Christophe Marchand, Lin-kun An, Yves Pommier

Keywords(s): CANCER, Combination Therapies, Pommier, therapeutic, Topoisomerase 2 (TOP2), Tyrosyl-DNA Phosphodiesterase 2 (TDP) Inhibitors

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics