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2,2'-Bipyridyl, a Ferrous Chelator, Prevents Vasospasm in a Primate Model of Subarachnoid Hemorrhage
Case ID:
TAB-320
Web Published:
12/6/2022
Description:
Subarachnoid hemorrhage (SAH) occurs in 28,000 people per year in North America. Symptomatic vasospasm occurs in the majority of individuals suffering SAH and is the most common cause of morbidity and mortality in patients reaching neurological care. Specifically, vasospasm causes cerebral ischemia or stroke, and the prevention of vasospasm could prevent stroke and death as well as allow physicians more freedom in scheduling surgery when the operative risks are lower.
Intravenous administration of 2,2'-bipyridyl successfully prevented vasospasm in a reliable primate model of subarachnoid hemorrhage. Bipyridyl may provide a safe, cost-effective and reliable therapy for vasospasm in the clinical setting. Additional ferrous chelates, which may also prove effective, are also embodied in the invention.
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Direct Link:
https://nih.technologypublisher.com/tech?title=2%2c2%27-Bipyridyl%2c_a_Ferrou s_Chelator%2c_Prevents_Vasospasm_in_a_Primate_Model_of_Subarachnoid_Hemorrhage
Category(s):
Licensing
Therapeutics
Neurology
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For Information, Contact:
Inteum Admin
NIH Technology Transfer
Inventors:
Laura Horky
Keywords:
NB1HXX
NBXXXX
NXXXXX
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