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Creation of a High-density Screening Format and the Identification of Small Molecule Inhibitors of the SIX/EYA Interaction for the Treatment of Cancers
Case ID:
TAB-3594
Web Published:
12/6/2022
Description:
The technology includes the creation of a high-throughput assay and the identification and use of small molecules that inhibit the SIX/EYA interaction as a treatment for cancer. The Eya proteins are phosphatases that form a complex and are activated by the Six family of homeobox transcription factors. The interaction of Eya and Six mediates breast cancer cell transformation, migration, invasion and metastasis. An assay was designed to screen a large collection of compounds to identify inhibitors of the SIX/EYA interaction.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Creation_of_a_High-density_Scr eening_Format_and_the_Identification_of_Small_Molecule_Inhibitors_of_the_SIX %2fEYA_Interaction_for_the_Treatment_of_Cancers
Category(s):
Research Materials
Therapeutics
Oncology
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For Information, Contact:
Suryanarayana Vepa
Technology Licensing Specialist
NIH Technology Transfer
301-827-7181
sury.vepa@nih.gov
Inventors:
Marc Ferrer-Alegre
Xin Hu
Juan Marugan
Lesley Mathews
Heide Ford
Melanie Blevins
Rebecca Mull
Rui Zhao
Keywords:
cancers
Identification
Identifying
Inhibitors
INTERACTION
Listed LPM Vathyam as of 4/15/2015
Method
MOLECULE
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
SIX/EYA
Small
treatment
VCXXXX
WIXXXX
WKXXXX
XEXXXX
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