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Isolation, Cloning and Characterization of New Adeno-Associated Virus (AAV) Serotypes
Case ID:
TAB-1157
Web Published:
12/6/2022
Description:
Adeno-associated viruses (AAV) are used in gene delivery, but with limited success due to toxicity. The novel AAVs described in this technology may be more effective and useful in gene therapy applications.
This invention relates to new adeno-associated viruses (AAV), vectors and particles derived therefrom and also provides methods for delivering specific nucleic acids to cells using the AAV vectors and particles. The inventors cloned and sequenced the genomes of AAVs found in twelve (12) simian adenovirus isolates and determined that the AAVs were novel. Ten (10) of these isolates had high similarity to AAV1 and AAV6 (>98%). Despite the high homology to AAV6, these novel AAVs demonstrated distinct cell tropisms and reactivity towards a panel of lectins, suggesting that they may use a distinct entry pathway.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Isolation%2c_Cloning_and_Chara cterization_of_New_Adeno-Associated_Virus_(AAV)_Serotypes
Category(s):
Therapeutics
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For Information, Contact:
Vladimir Knezevic
Senior Advisor for Commercial Evaluations
NIH Technology Transfer
vlado.knezevic@nih.gov
Inventors:
John (Jay) Chiorini
Michael Schmidt
Keywords:
Adeno-associated
CHARACTERIZATION
Cloning
GB2A2X
GB2AXX
GB2XXX
GBXXXX
GXXXXX
Isolation
Novel
Serotypes
virus
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