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Molecular Cloning and Characterization of SNAPIN: A Synaptic Vesicle Protein Implicated in Neurotransmitter
Case ID:
TAB-1282
Web Published:
12/6/2022
Description:
Neurotransmitter release is dependent on a binding complex (designated as SNAR) of three proteins, synaptic-vesicle-associated protein synaptobrevin/VAMP, syntaxin and SNAP-25 (snaptosome-associated protein-25) with results in a calcium dependent fusion between synaptic vesicles and the presynaptic terminal. SNAPIN, a neuron specific protein found predominately on synaptic vesicles, binds to the SNAR complex, most likely to the SNAP-25. Although the complete function of SNAPIN has not been determined, it appears to regulate a step between vesicle docketing and neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs, which then leads to the final fusion step triggered by calcium influx into nerve terminals through voltage-dependent calcium channels.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Molecular_Cloning_and_Characte rization_of_SNAPIN%3a_A_Synaptic_Vesicle_Protein_Implicated_in_Neurotransmitter
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For Information, Contact:
Inteum Admin
NIH Technology Transfer
Inventors:
Jeffrey Ilardi
Zu-hang Sheng
Keywords:
ac5AXX
AC5XXX
ACXXXX
AXXXXX
CHARACTERIZATION
Cloning
implicated
Listed LPM Maddox as of 4/15/2015
Molecular
NEUROTRANSMITTER
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
Protein
Snapin:
SYNAPTIC
VESICLE
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