Search Results - antibody+drug+conjugate

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Development of Next Generation Antibody Drug Conjugates (ADCs) Against CD276

Abstract: Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. Angiogenesis occurs during normal growth and development (physiological angiogenesis) and during the growth of solid tumors (pathological angiogenesis). CD276, also known as B7-H3, is a cell surface tumor endothelial marker that is highly expressed in the tumor...

Published: 5/22/2024 | Inventor(s): Brad St. Croix, Yang Feng, Steven Seaman

Keywords(s): ADC, antibody drug conjugate, B7-H3, CD276, Immunotherapy, Monoclonal Antibody, St. Croix

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Her2 Monoclonal Antibodies, Antibody Drug Conjugates as Cancer Therapeutics

Abstract: Antibody drug conjugates (ADC) can demonstrate high efficacy as cancer therapeutics, however, much more can be done to improve their efficacy and safety profile. Site-specific antibody drug conjugation is a promising way to do this. Scientists at the NCI’s Laboratory of Experimental Immunology have identified a fully human monoclonal antibody,...

Published: 5/22/2024 | Inventor(s): Dimiter Dimitrov, Zhongyu Zhu, Pradman Qasba, Boopathy Ramakrishnan

Keywords(s): ADC, antibody drug conjugate, Dimitrov, HER2, Her2 positive, Her2-overexpression

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology