Search Results - ashok+kulkarni

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Alpha-galactosidase-A Knockout Mouse Model for Studying Fabry Disease

This technology includes an alpha-galactosidase-A knockout mouse model that can be used to study Fabry disease, an X-linked lysosomal storage disorder. Alpha-galactosidase-A is a crucial enzyme responsible for the breakdown of glycolipids, particularly globotriaosylceramide (Gb3), within lysosomes. In Fabry disease, a rare and inherited lysosomal storage...

Published: 4/8/2024 | Inventor(s): Toshio Ohshima, Ashok Kulkarni, Roscoe Brady, Gary Murray

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought > Materials Available, ResearchProducts > Animal Models, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Metabolic Disease

mNFHcre Transgenic Mice

Knockout mouse is a valuable model to study biological functions of target genes. When Cre expressing mice are bred with mice containing a loxP-flanked gene, the gene between the loxP sites will be deleted in the offsprings. Scientists at the NIH have generated mNF-H-cre transgenic mouse lines that express Cre recombinase under the control of the promoter...

Published: 7/25/2024 | Inventor(s): Ashok Kulkarni

Keywords(s): Listed LPM Tong as of 4/15/2015, Mice, MNFHcre, MNHFcre, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RXXXXX, TRANSGENIC, VEXXXX, WIXXXX, XEXXXX, YCXXXX

Category(s): TherapeuticArea > Neurology, Application > Therapeutics, Application > Research Materials