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Novel Immunotherapy for Cancer Treatment: Chimeric Antigen Receptors Targeting CD70 Antigen

Abstract: Scientists at the NCI's Surgery Branch have developed anti-CD70 chimeric antigen receptors (CARs) to treat cancers. CD70 is an antigen that is expressed on a variety of human cancers such as renal cell carcinoma, glioblastoma, non-Hodgkin's lymphoma, and chronic lymphocytic leukemia. The anti-CD70 CARs are hybrid proteins consisting of a receptor...

Published: 4/8/2024 | Inventor(s): Qiong Wang, Zhiya Yu, James Yang

Keywords(s): CARS, CD70, chimeric antigen receptor, T-cell reprogramming

Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing

Cancer Therapeutic Based on T Cell Receptors Designed to Regiospecifically Release Interleukin-12

Abstract: Adoptive immunotherapy is a promising new approach to cancer treatment that engineers an individual''s innate and adaptive immune system to fight against specific diseases, including cancer with fewer side-effects and more specific anti-tumor activity in individual patients. T cell receptors (TCRs) and Chimeric Antigen Receptors (CARs) are...

Published: 4/8/2024 | Inventor(s): Richard Morgan, Nicholas Restifo, Steven Rosenberg, Ling Zhang

Keywords(s): CARS, chimeric antigen receptor, human interleukin 12, IL-12, T Cell Receptor, TCRs

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology