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Sensitizing Cancer Cells to DNA Targeted Therapies

Abstract: Chk2 is a protein kinase activated in response to DNA double strand breaks. In normal tissues, Chk2 phosphorylates and thereby activates substrates that induce programmed cell death, or apoptosis, via interactions with p53, E2F1, PML proteins. In cancer tissues, where apoptosis is suppressed, Chk2 phosphorylates and inactivates cell cycle...

Published: 4/8/2024 | Inventor(s): Yves Pommier, Dominic Scudiero, Christopher Self, Robert Shoemaker, David Waugh, Guangtao (George) Zhang, John Cardellina, Michael Currens, Andrew Collasanti, Charles Cook, Andrew Jobson, Sudhir Kondapaka, George Lountos

Keywords(s): Anti-cancer Therapeutic, Chk2 Inhibitors, Sensitizing Agent for current DNA-damaging cancer therapeuti

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics