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Natural product-based anti-cancer agents: aza-Englerin analogues

Abstract: Chemotherapy resistance in a wide array of cancers is often associated with enhanced glucose uptake and dysregulation of the insulin signaling pathway. Therapeutics capable of inhibiting insulin signaling would be valuable as a stand-alone treatment and for sensitizing resistant tumors to standard chemotherapy regiments. Researchers at NCI’s...

Published: 7/3/2024 | Inventor(s): Willaim Chain, John Beutler, William Figg, Joe Ramos, Florian Suizmaier, Zhenwu Li, Daniel Fash, Ian Talisman, Cody Peer

Keywords(s): Ewing, Glycolytic, insulin, Resistance, Sarcoma

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology