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Calcium (Ca2+) Flux-Dependent Method to Detect and Isolate Tumor Reactive T Cell Receptors (TCRs)

Abstract: T cells with T cell receptors (TCRs) for cancer-specific antigens are used for adoptive cell therapy (ACT), wherein a patient’s T cells are redirected against their own cancer. However, these isolated T cells may require further ex vivo manipulation to enhance their anti-tumor activity. The ex vivo manipulation of these T cells, or the selection...

Published: 4/8/2024 | Inventor(s): Douglas Palmer, Anna Pasetto, Nicholas Restifo, Steven Rosenberg

Keywords(s): act, Adoptive Cell Transfer, CA2+, Calcium Ion, Immunotherapy, Rosenberg, T Cell Receptor, TCR, tumor

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology