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Human Antibody for Deploying CH2-Based Therapeutics

Abstract: The National Cancer Institute seeks parties to license fully human antibodies for CH2-based research materials. Recently, isolated immunoglobulin constant CH2 domains were proposed as scaffolds for construction of libraries containing diverse binders that could confer some effector functions. As a fragment in all IgGs, which are at high concentrations...

Published: 4/22/2025 | Inventor(s): Dimiter Dimitrov, Rui Gong

Keywords(s): CH2, conformational epitope, Dimitrov, effector functions, IgG

Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology