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Derivation of a >25 million-year-old Adeno-associated Virus Coat Protein Sequence for Gene Transfer Studies

This technology includes a novel capsid protein for recombinant adeno-associated virus (AAV)-mediated gene transfer evaluation. We have identified a "fossilized" endogenous AAV sequence element (referred to as mAAV-EVE) within the germline of an ancient lineage of Australian marsupials and have cloned and sequenced mAAV-EVE orthologs from...

Published: 8/12/2024 | Inventor(s): Richard Smith, Robert Kotin, Claus Hallwirth, Ian Alexander

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Category(s): Application > Therapeutics, Collaboration Sought > Licensing