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A3 Adenosine Receptor Positive Allosteric Modulators

Selective A3AR agonists are sought as potential agents for treating inflammatory diseases, chronic pain, cancer and non-alcoholic steatohepatitis (NASH). NIDDK investigators have invented new chemical composition as positive allosteric modulators (PAMs) of the A3AR. These chemical compounds contain sterically constrained, bridged modifications and...

Published: 4/8/2024 | Inventor(s): Kenneth Jacobson, Lucas Fallot, Rama Ravi, Balaram Pradhan, John Auchampach, Courtney Fisher

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Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing