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Activation of Recombinant Diphtheria Toxin Fusion Proteins by Specific Proteases Highly Expressed on the Surface of Tumor Cells

This invention relates to diphtheria toxin fusion proteins comprising a diphtheria toxin (DT) cell-killing component and a cell-binding component such as granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin 2 (IL-2), or epidermal growth factor (EGF). Receptors for the latter three materials are present on many types of cancer cells;...

Published: 7/25/2024 | Inventor(s): Stephen Leppla, Shihui Liu, Manuel Osorio, Jennifer Avallone

Keywords(s): CBXXXX, CXXXXX, DIPHTHERIA

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics