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Abstract: Soluble forms (sCD4) of human CD4, the HIV-1 primary receptor, are potent HIV-1 entry inhibitors. Both four-domain (D1-4) and two-domain (D1D2) sCD4 and their fusion proteins have been tested as candidate therapeutics in animal models and in human clinical trials and were well tolerated by patients with no significant clinical or immunologic...

Published: 5/22/2024 | Inventor(s): Dimiter Dimitrov, Weizhao Chen, Prabakaran Ponraj

Keywords(s): CD4, entry inhibitor, HIV, MHCII, soluble expression

Category(s): Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Oncology