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Dopamine D3 Receptor Agonist Compounds, Methods of Preparation, Intermediates Thereof, and their Methods of Use

Abstract: Due to the large degree of homology among dopamine D2-like receptors, discovering ligands capable of discriminating between the D2, D3, and D4 receptor subtypes remains a significant challenge. The development of subtype-selective pharmaceutical small molecules to activate (agonists) signals regulated by D2-like receptors has been especially...

Published: 4/8/2024 | Inventor(s): Amy Newman, Alessandro Bonifazi, Francisco Battiti, Sophe Cemaj

Keywords(s): D3R agonists, Dopamine, Newman, Parkinson’s Disease, Restless Legs Syndrome, RLS, small molecule

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Neurology

Atypical Inhibitors of Monoamine Transporters; Method of Making; and Use Thereof

Abstract: Substance use disorder is a chronic medical condition, taking its toll on our public health care and judicial systems in an economically unsustainable way. More than 20 million Americans suffer from substance use disorders. Certainly, the development of prevention and treatment options as alternatives to incarceration is the appropriate and...

Published: 4/8/2024 | Inventor(s): Amy Newman, JoLynn Giancola, Rachel Slack, Jianjing Cao

Keywords(s): ADHD, dopamine reuptake inhibitor, Newman, sleep disorders, Substance use disorder

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology