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The present invention is directed to a transgenic rat model of Alzheimer's Disease (AD) termed TgF344-19+/-. The invention rat overexpresses two human genes (APPswe and PS1deltaE9 genes), each of which are believed to be independent dominant causes of early-onset AD. The hemizygote exhibits major features of AD pathology (i.e., dense and diffuse amyloid...

Published: 7/25/2024 | Inventor(s): Daniel (missing inventor) Ye, Robert Cohen

Keywords(s): ALZHEIMER'S, Disease, Model, rat, RXXXXX, TgF344+/-

Category(s): Collaboration Sought > Licensing, Application > Research Materials