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Cancer Immunotherapies That Harness Pre-Existing Antiviral Immunity

Abstract: The treatment of cancer using immunotherapies has garnered substantial attention and excitement considering the clinical benefits observed in patient populations previously refractory to treatment. Tumor infiltrating T cells can significantly impact cancer progression and immunotherapy response; however, immunosuppressive tumor microenvironments...

Published: 4/8/2024 | Inventor(s): John Schiller, Nicolas Cuburu, Douglas Lowy

Keywords(s): Antiviral Cellular Immunity, Epitope Spreading, HCMV Antigens, human cytomegalovirus, Immunotherapy, Schiller, solid tumor

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Efficient Cell-Free Production of Papillomavirus Gene Transfer Vectors

Abstract: Papillomavirus pseudoviruses that comprise the L1/L2 capsid proteins can package a wide variety of non-viral DNA plasmids and deliver the packaged genetic material to cells. This function makes them attractive candidates as targeted gene delivery vehicles. Current methods for the efficient production of papillomavirus pseudoviruses require...

Published: 4/8/2024 | Inventor(s): John Schiller, Carla Correia Cerqueira, Patricia Day, Douglas Lowy, David Fitzgerald

Keywords(s): CANCER, cancer therapeutic, cell-free production, papillomavirus, Schiller, therapeutic, tumor therapy, Vaccine, vectors, virus based gene transfer vectors

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology