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Improved CD22 Binders for Effective Immunotherapy Against Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Abstract: Targeting the CD22 receptor of B-cells with chimeric antigen receptor (CAR)-T cells has been a promising new therapy to treat B-cell malignancies in clinical trials, inducing remission in 70% of patients with relapsed acute lymphoblastic leukemia (ALL). However, diminished CD22 expression on B-cell surface can lead to relapse and decreased...

Published: 8/14/2024 | Inventor(s): Dimiter Dimitrov, Zhongyu Zhu, Terry Fry, Sneha Ramakrishna

Keywords(s): Acute Lymphoblastic Leukemia, ALL, B Cell, CAR, CAR-T, CD22, chimeric antigen receptor, Dimitrov, T cell

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing