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GLI-similar (Glis) 1-3 proteins constitute a subfamily of the Krüppel-like zinc finger transcription factors that are closely related to the Gli family. Mutations in human GLIS3 have been implicated in a syndrome characterized by neonatal diabetes and congenital hypothyroidism (NDH) and in some patients accompanied by polycystic kidney disease, glaucoma,...

Published: 7/25/2024 | Inventor(s): Kristin Lichti-Kaiser, Hong Soon Kang, Anton Jetten

Keywords(s): ACXXXX, AXXXXX, GCXXXX, GLIS3, GXXXXX, Knock, KO, Mice, Mice:, RXXXXX, SELECTIVE, TISSUES, Which

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Therapeutics

Novel Genetic Tristetraprolin (TTP) Knock-in Mouse

Tristetraprolin (TTP) is the prototype member of a small family of RNA binding proteins that bind to specific types of AU-rich elements in the 3'UTRs of target mRNAs and promote their rapid turnover. One of the targets destabilized by TTP is Tumor necrosis factor alpha (TNF). TNF has long been a target of anti-inflammatory drug development, in which...

Published: 7/25/2024 | Inventor(s): Perry Blackshear

Keywords(s): Cells, DISEASES, Increasing, INFLAMMATORY, Listed LPM Reichman as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, THERAPY, TISSUES, Tristetraprolin, TTP, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials