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Reversible SNAP-Tag and CLIP-Tag Ligands for Live Cell Imaging

Recently-developed protein tags enable the specific covalent attachment of synthetic ligands, incorporating fluorophores or other substituted groups, to fusion proteins containing these tags. For example, SNAP and CLIP tags bind O6-benzylguanine-containing and O2-benzylcytosine containing ligands respectively, which can be derivatized with a wide variety...

Published: 4/8/2024 | Inventor(s): Julie Donaldson, Nelson Cole

Keywords(s): ACXXXX, AXXXXX, CLIP, CLIP-tag, fluorescent, Fluorescent probe, IMAGING, LIGANDS, Patent Category - Biotechnology, REVERSIBLE, SNAP, SNAP-tag, Trafficking

Category(s): Collaboration Sought > Licensing