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Personalized Tumor Vaccine and Use Thereof for Cancer Immunotherapy

Abstract: Immune checkpoint inhibitors (ICIs) vastly improved the outcome of various advanced cancers; however, many are less likely to respond to single-agent ICI. Tumors with low T-cell infiltration are "immunologically cold" and less likely to respond to single-agent ICI therapy. This diminished response is presumably due to the lack of neoantigens...

Published: 4/8/2024 | Inventor(s): Zhengping (Ping) Zhuang, Karel Pacak, Jan Zenka, Rogelio Medina, Herui Wang, Sze Chun (Winson) Ho

Keywords(s): Anti-CD40-Monoclonal Antibody, CANCER, ICI, Immune Checkpoint Inhibitors, Mannan-BAM, Oncology, TLR, Toll-like receptor, Tumor Vaccine, Zhuang

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics