Search Results - wnt

3 Results

Sort By:

Methods for Producing Stem Cell-Like Memory T Cells for Use in T Cell-Based Immunotherapies

Abstract: T cells currently employed for T cell-based immunotherapies are often senescent, terminally differentiated cells with poor proliferative and survival capacity. Recently, however, scientists at the National Cancer Institute (NCI) identified and characterized a new human memory T cell population with stem cell-like properties. Since these T...

Published: 4/17/2024 | Inventor(s): Luca Gattinoni, Nicholas Restifo, Mario Roederer, Enrico Lugli

Keywords(s): anti-tumor activity, CANCER, Gattinoni, GSK-3beta, Immunotherapy, Infection, Stem Cell, T cell, WNT

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Therapeutics

Method To Treat Numerous Dermatological Conditions

Abstract: The National Cancer Institute's Laboratory of Cell Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the use of DKK1 to treat abnormal pigmentation of the skin or to regulate hair growth. Palmoplantar skin is found on a limited number of...

Published: 5/21/2024 | Inventor(s): Vincent Hearing, Yuji Yamaguchi, Thierry Passeron

Keywords(s): Dickkopf 1, Dkk1, palmoplantar fibroblasts, WNT

Category(s): Application > Therapeutics, TherapeuticArea > Dermatology, Collaboration Sought > Licensing

Brain endothelial reporter cells

Abstract: Aberrant function of the WNT-b-catenin pathway is a common underlying cause of tumorigenesis. Despite the attractiveness of the WNT-b-catenin pathway as a therapeutic target, WNT dependent cell signaling is also crucial for normal tissue development, and is ubiquitous in all organs. As a result, WNT-b-catenin pathway inhibitors cause many...

Published: 8/14/2024 | Inventor(s): Brad St. Croix

Keywords(s): catenin, GPR 124, St. Croix, TEM5, WNT

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Research Materials