Search Results - xiuxiu+lu

1 Results

Sort By:

A New Molecular Scaffold for Targeting hRpn13 as a Treatment for Cancer

This technology includes a new chemical scaffold (with lead compound XL5) against hRpn13 that induces apoptosis, which may have clinical efficacy against cancer. The structure of XL5-conjugated hRpn13 guided the design of XL5-PROTAC degrader compounds that exhibit greater efficacy than previous hRpn13-targeting compounds, as evaluated by selectivity...

Published: 8/12/2024 | Inventor(s): Venkatareddy Sabbasani, Kylie Walters, Xiuxiu Lu, Nadya Tarasova, Rolf Swenson

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology