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Chimeric Antigen Receptors to CD276 for Treating Cancer

Abstract: Chimeric antigen receptors (CARs) are hybrid proteins consisting of an antibody binding fragment fused to protein signaling domains that cause T-cells which express the CAR to become cytotoxic. Once activated, these cytotoxic T-cells can selectively eliminate the cells which they recognize via the antibody binding fragment of the CAR. By...

Published: 4/8/2024 | Inventor(s): Crystal Mackall, Yongzhi Cui

Keywords(s): adoptive cell therapy, ANTIBODY, antigen-binding fragment, CAR, Neuroblastoma

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology