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Caspase Inhibitors Useful for the Study of Autoimmune or Inflammatory Diseases
Case ID:
TAB-2079
Web Published:
12/6/2022
Description:
Novel and potent caspase 1 inhibitors are available for licensing. In particular, this technology discloses potent and selective caspase 1 inhibitors that target the active site of the enzyme. Caspase 1 is known to play a pro-inflammatory role in numerous autoimmune and inflammatory diseases and therefore represents an excellent target for treatment of a broad range of diseases, including but not limited to Huntington's, amyotrophic lateral sclerosis, ischemia, rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, and sepsis. Not surprisingly this enormous potential has resulted in at least three caspase 1 inhibitors entering clinical trials (VX-740, IDN-6556, and VX-765) in recent years.
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Direct Link:
https://nih.technologypublisher.com/tech/Caspase_Inhibitors_Useful_for_the_St udy_of_Autoimmune_or_Inflammatory_Diseases
Category(s):
Collaboration
Licensing
Diagnostics
Research Materials
Therapeutics
Immunology
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For Information, Contact:
Suryanarayana Vepa
Technology Licensing Specialist
NIH Technology Transfer
301-827-7181
sury.vepa@nih.gov
Inventors:
Matthew Boxer
Craig Thomas
Keywords:
1
Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis 1; Amyotrophic lateral scleros
Amyotrophic lateral sclerosis 6
Caspase
IB3XXX
IBXXXX
Inflammatory bowel disease 1
inhibitor
IXXXXX
Lou Gehrig's disease
Patent Category - Chemistry
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