This technology includes a number of RNAs that can induce strong fluorescence of otherwise non-fluorescent small molecules to be used for imaging and analysis of RNA. These RNAs have many potential applications as tags for live-cell imaging of cellular RNAs, as well as reporters for in vitro diagnostics. The "Mango" family of fluorescent RNA-fluorophore complexes has been previously reported. Work in this laboratory led to the determination of the 30, atomic structure of four different versions of Mango RNAs (Mango-I, Mango-II, Mango-Ill, Mango IV), and these structures were used by the laboratory to generate versions with greatly improved fluorescent and biochemical properties.