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Inhibition of Thioredoxin Reductase 1 (Trxr1) by Pyridine Compounds for Cancer Treatment
Case ID:
TAB-3604
Web Published:
12/6/2022
Description:
This technology includes the use of pyridines for anticancer treatment. A common feature of cancer cells is a high level of reactive oxygen species with a concomitant increase of two antioxidative systems to combat the toxicity: the glutathione and thioredoxin systems. Inhibiting either, or both, of these systems is a promising avenue to target cancer cells. Thioredoxin Reductase 1 (Trxr1) is an important selenoprotein in the thioredoxin antioxidative system which has been implicated as a potential anti-cancer target. The inventors have found that pyridinyl sulphone compounds may achieve highly selective inhibition of cytosolic thioredoxin reductase (Trxr1) by strongly-binding (in some cases, effectively irreversibly) without causing significant inhibition of glutathione reductase, an important protein in the gluthathione antioxidative system.
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Direct Link:
https://nih.technologypublisher.com/tech/Inhibition_of_Thioredoxin_Reductase_ 1_(Trxr1)_by_Pyridine_Compounds_for_Cancer_Treatment
Category(s):
Research Materials
Oncology
Therapeutics
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For Information, Contact:
Suryanarayana Vepa
Technology Licensing Specialist
NIH Technology Transfer
301-827-7181
sury.vepa@nih.gov
Inventors:
Ajit Jadhav
Diane Luci
Thomas Dexheimer
Anton Simeonov
Nathan Coussens
David Maloney
Keywords:
CANCER
Novel
PYRIDINES
Their
treatment
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