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Lymphoblastoid Cell Lines with a Specific Allele of ABCA7 Gene for the Screening of Small Molecules for Therapeutic Development
Case ID:
TAB-3645
Web Published:
12/6/2022
Description:
This technology includes lymphoblastoid cell lines from individuals genotyped as carrying the minor (G) allele of ABCA7 SNP rs113809142 [ss491752998; SNV-chr19-1007244], to be used for small molecule screening and eventual therapeutic development. The ABCA7 gene is the ATP-binding cassette, sub-family A (ABC1), member 7. It encodes a protein that is a transporter and has been associated with such diseases as neonatal respiratory failure and Asperger's syndrome. It is also known to play a role in phagocytosis of apoptotic cells by macrophages and may mediate cholesterol efflux.
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Direct Link:
https://nih.technologypublisher.com/tech/Lymphoblastoid_Cell_Lines_with_a_Spe cific_Allele_of_ABCA7_Gene_for_the_Screening_of_Small_Molecules_for_Therapeu tic_Development
Category(s):
Endocrinology
Therapeutics
Dental
Oncology
Ophthalmology
Research Materials
Cardiology
Infectious Disease
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For Information, Contact:
Eggerton Campbell
Licensing And Patenting Manager
NIH Technology Transfer
301-402-1648
eggerton.campbell@nih.gov
Inventors:
James ("Jim") Mullikin
Jennifer Johnston
Leslie Biesecker
Keywords:
ABCA7
ALLELE
Cell
Gene
Lines
Listed LPM Contreras as of 4/15/2015
Lymphoblastoid
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
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