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Method of Inducing Memory B Cell Development and Terminal Differentiation
Case ID:
TAB-1338
Web Published:
12/6/2022
Description:
Cytokines exert their respective biochemical and physiological effects by binding to specific receptor molecules, which then stimulate signal transduction pathways. Interleukin-21 (IL-21) is a type I cytokine whose receptor is expressed on T, B, and NK cells.
This invention specifically relates to the use of IL-21 to induce differentiation of immature B cells into memory B cells and plasma cells. This invention includes claims of methods for inducing differentiation of a B cell progenitor into memory B cells and/or plasma cells. It also includes claims for enhancing an immune response, treating subjects that lack memory B cells and plasma cells and methods for increasing or decreasing the number of B cells. This invention could conceivably be used in treating or preventing inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.
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Direct Link:
https://nih.technologypublisher.com/tech/Method_of_Inducing_Memory_B_Cell_Dev elopment_and_Terminal_Differentiation
Category(s):
Licensing
Diagnostics
Research Materials
Therapeutics
Oncology
Immunology
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For Information, Contact:
Vincent Kolesnitchenko
Technology Development Specialist
NIH Technology Transfer
301-594-4115
vk5q@nih.gov
Inventors:
Peter Lipsky
Keywords:
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