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Methods for Using Modulators of Extracellular Adenosine or an Adenosine Receptor To Enhance Immune Response and Inflammation
Case ID:
TAB-3809
Web Published:
12/6/2022
Description:
Local inflammation processes are crucially important in the host defense against pathogens and for successful immunization because proinflammatory cytokines are necessary for initiation and propagation of an immune response. However, normal inflammatory responses are eventually terminated by physiological termination mechanisms, thereby limiting the strength and duration of immune responses, especially to weak antigens. The inventors have shown that adenosine A2a and A3a receptors play a critical role in down-regulation of inflammation in vivo. They act as the physiological termination mechanism that can limit the immune response. Thus, a method was developed for inhibiting signaling through the adenosine receptor to prolong and intensify the immune response. The method involves administering either an adenosine-degrading drug or an adenosine receptor agonist. These compounds can be also used as vaccine adjuvants and treatments for accomplishing targeted tissue damage such as for tumor destruction.
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Direct Link:
https://nih.technologypublisher.com/tech/Methods_for_Using_Modulators_of_Extr acellular_Adenosine_or_an_Adenosine_Receptor_To_Enhance_Immune_Response_and_ Inflammation
Category(s):
Immunology
Oncology
Infectious Disease
Diagnostics
Therapeutics
Vaccines
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For Information, Contact:
Yogikala Prabhu
Technology Transfer Patent Specialist
NIH Technology Transfer
+1 240 276 5530
yogikala.prabhu@nih.gov
Inventors:
Akio Ohta
Michail Sitkovsky
Keywords:
2IXXXX
2JXXXX
CB3CXX
CB6XXX
Controlling
DC1XXX
IA3XXX
Inflammation
Listed LPM Thalhammer-Reyero as of 4/15/2015
Method
Patent Category - Chemistry
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
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