Oral Treatment of Hemophilia

Description:
This invention portrays a simple method for treatment of antigen-deficiency diseases by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. This method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.
Patent Information:
For Information, Contact:
Charles Rainwater
Technology Development Specialist
NIH Technology Transfer
301-496-5717
crainwater@mail.nih.gov
Inventors:
Oral Alpan
Polly Matzinger
Tirumalai Kamala
William Velander
Keywords:
3-@hydroxyacyl-coa dehydrogenase deficiency
HAD deficiency
Hemophilia A
Hemophilia B
HIS deficiency
Histidinemia
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