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Small Interfering RNA Inhibition of Cannabanoid-1 Receptor (CB1R) for Treating Type 2 Diabetes
Case ID:
TAB-2655
Web Published:
12/6/2022
Description:
The invention pertains to the use of glucan encapsulated non-immunostimulatory small interfering RNAs (siRNAs) to treat type-2 diabetes. Endocannabinoids (EC) are lipid signaling molecules that act on the same cannabinoid receptors that recognize and mediate the effects of endo- and phytocannabanoids. EC receptor CB1R activation is implicated in the development of obesity and its metabolic consequences, including insulin resistance and type 2 diabetes. Beta-cell loss has been demonstrated in a Zucker diabetic fatty (ZDF) rat model of type-2 diabetes through CB1R-mediated activation of a macrophage-mediated inflammatory response. Conversely, rats treated with a peripheral CB1R antagonist restores normoglycemia and preserves beta-cell function. Similar results are seen following selective in vivo knockdown of macrophage CB1R by daily treatment of ZDF rats with the instant D-glucan-encapsulated CB1R Small interfering RNA (siRNA). Knock-down of CB1R with using glucan encapsulated siRNA may represent a new commecializable method of treating type-2 diabetes or preventing the progression of insulin resistance to overt diabetes.
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Direct Link:
https://nih.technologypublisher.com/tech/Small_Interfering_RNA_Inhibition_of_ Cannabanoid-1_Receptor_(CB1R)_for_Treating_Type_2_Diabetes
Category(s):
Licensing
Research Materials
Diagnostics
Therapeutics
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For Information, Contact:
Michael Shmilovich
Senior Licensing And Patenting Manager
NIH Technology Transfer
301-435-5019
shmilovm@nih.gov
Inventors:
Tony Jourdan
Michael Czech
Myriam Aouadi
George Kunos
Keywords:
CB1
DIABETES
GB1AXX
GB1XXX
GBXXXX
GXXXXX
IBXXXX
IXXXXX
Knockdown
MACROPHAGES
RECEPTORS
SELECTIVE
SiRNA-mediated
treatment
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