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Identification and Use of a Novel Functionally Selective GHSR1a Ghrelin Receptor Inhibitor, including NCGC00538279, for the Treatment of Food and Chemical Addiction
Case ID:
TAB-3591
Web Published:
12/6/2022
Description:
This technology includes a chemical series, including the NCGC00538279 compound, that selectively activates the GHSR1a G-protein pathway for calcium mobilization while only partially activating the beta-arrestin-2 translocation pathway. The resulting chemical series may be therapeutically valuable for addictive disorders. Activation of the GHSR1a G-protein pathway promotes production and secretion of multiple hormones, including insulin, growth hormone, and IGF1. Activation of the beta-arrestin-2 pathway stimulates dopamine production and may mediate addictive behaviors. Work with non-selective antagonists in models has indicated good in vivo efficacy results for treating addictive disorders. However, long term exposure to this type of antagonist triggers multiple undesirable side effects due to their capacity to inhibit production of numerous hormones. A select antagonist has the potential to have positive therapeutic effects without the side effects.
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Direct Link:
https://nih.technologypublisher.com/tech?title=Identification_and_Use_of_a_No vel_Functionally_Selective_GHSR1a_Ghrelin_Receptor_Inhibitor%2c_including_NC GC00538279%2c_for_the_Treatment_of_Food_and_Chemical_Addiction
Category(s):
Neurology
Therapeutics
Endocrinology
Research Materials
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For Information, Contact:
Ami Gadhia
Technolgy and Patent Specialist
NIH Technology Transfer
301-827-7159
ami.gadhia@nih.gov
Inventors:
Noel Southall
Marc Ferrer-Alegre
Daniel Jansen
Mark Henderson
Xin Hu
David Kim
Juan Marugan
Keywords:
ADDICTION
Chemical
FOOD
Funtionally
Ghrelin
LIGAND
NCG00538279
Novel
RECEPTOR
SELECTIVE
treatment
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VGXXXX
WIXXXX
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