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Identification and Use of a Novel Functionally Selective GHSR1a Ghrelin Receptor Inhibitor, including NCGC00538279, for the Treatment of Food and Chemical Addiction

This technology includes a chemical series, including the NCGC00538279 compound, that selectively activates the GHSR1a G-protein pathway for calcium mobilization while only partially activating the beta-arrestin-2 translocation pathway. The resulting chemical series may be therapeutically valuable for addictive disorders. Activation of the GHSR1a G-protein...

Published: 7/25/2024 | Inventor(s): Noel Southall, Marc Ferrer-Alegre, Daniel Jansen, Mark Henderson, Xin Hu, David Kim, Juan Marugan

Keywords(s): ADDICTION, Chemical, FOOD, Funtionally, Ghrelin, LIGAND, NCG00538279, Novel, RECEPTOR, SELECTIVE, treatment, VEXXXX, VGXXXX, WIXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Neurology, Application > Therapeutics, TherapeuticArea > Endocrinology, Application > Research Materials

Multiplex Assay for Rapid Salmonella Serotyping from Human, Animal, Food and Environmental Sources

CDC researchers have developed a bead-based nucleic acid assay for serotyping members of the Salmonella genus; this assay will identify serotypes for approximately 95% of all human-obtained Salmonella isolates in the United States. Presently, production and quality control for the more than 250 antisera required to cover the >2,500 known serotypes using...

Published: 7/25/2024 | Inventor(s): John McQuiston, Collette Fitzgerald Leaumont, Patricia Fields

Keywords(s): AA5XXX, AAXXXX, AFXXXX, assay, Bead, Beads, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, diagnostic, Diagnostic assay, DXXXXX, FOOD, FOOD PATHOGEN, FOOD-ASSOCIATED, Foodborne, ivd, NAT, Nucleic, OID-NCEZID-DFWED, PLATE-BASED, RAPID, SALMONELLA, Serotype, SEROTYPING, VETERINARY, VJXXXX, VOXXXX, WBXXXX, WCXXXX, WFXXXX, WMXXXX, XEXXXX, YBXXXX, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Occupational Safety and Health