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Identification and Use of a Novel Functionally Selective GHSR1a Ghrelin Receptor Inhibitor, including NCGC00538279, for the Treatment of
Food
and Chemical Addiction
This technology includes a chemical series, including the NCGC00538279 compound, that selectively activates the GHSR1a G-protein pathway for calcium mobilization while only partially activating the beta-arrestin-2 translocation pathway. The resulting chemical series may be therapeutically valuable for addictive disorders. Activation of the GHSR1a G-protein...
Published: 10/28/2024
|
Inventor(s):
Noel Southall
,
Marc Ferrer-Alegre
,
Daniel Jansen
,
Mark Henderson
,
Xin Hu
,
David Kim
,
Juan Marugan
Keywords(s):
ADDICTION
,
Chemical
,
FOOD
,
Funtionally
,
Ghrelin
,
LIGAND
,
NCG00538279
,
Novel
,
RECEPTOR
,
SELECTIVE
,
treatment
,
VEXXXX
,
VGXXXX
,
WIXXXX
,
WKXXXX
,
XEXXXX
Category(s):
TherapeuticArea > Neurology
,
Application > Therapeutics
,
TherapeuticArea > Endocrinology
,
Application > Research Materials
Multiplex Assay for Rapid Salmonella Serotyping from Human, Animal,
Food
and Environmental Sources
CDC researchers have developed a bead-based nucleic acid assay for serotyping members of the Salmonella genus; this assay will identify serotypes for approximately 95% of all human-obtained Salmonella isolates in the United States. Presently, production and quality control for the more than 250 antisera required to cover the >2,500 known serotypes using...
Published: 10/28/2024
|
Inventor(s):
John McQuiston
,
Collette Fitzgerald Leaumont
,
Patricia Fields
Keywords(s):
AA5XXX
,
AAXXXX
,
AFXXXX
,
assay
,
Bead
,
Beads
,
CDC Docket Import
,
CDC Docket Import CDC Prosecuting
,
DA3XXX
,
DAXXXX
,
diagnostic
,
Diagnostic assay
,
DXXXXX
,
FOOD
,
FOOD
PATHOGEN
,
FOOD
-ASSOCIATED
,
Food
borne
,
ivd
,
NAT
,
Nucleic
,
OID-NCEZID-DFWED
,
PLATE-BASED
,
RAPID
,
SALMONELLA
,
Serotype
,
SEROTYPING
,
VETERINARY
,
VJXXXX
,
VOXXXX
,
WBXXXX
,
WCXXXX
,
WFXXXX
,
WMXXXX
,
XEXXXX
,
YBXXXX
,
Zoonotic
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
Application > Consumer Products
,
TherapeuticArea > Infectious Disease
,
Application > Diagnostics
,
Application > Occupational Safety and Health
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