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Anti-Py1235-Met Immunological Binding Reagent as Cancer Diagnostic

Abstract: This technology consists of highly specific rabbit monoclonal antibodies reactive with phosphorylated tyrosine located at amino acid 1235 in the human MET sequence. Binding to this pYl235 residue is independent of the phosphorylation of other tyrosines in the vicinity (1230 and 1234), does not cross-react with these nearby phosphotyrosine...

Published: 4/8/2024 | Inventor(s): Apurva Srivastava, Thomas Pfister, Mario Navas, James Doroshow, Ralph Parchment

Keywords(s): ANTIBODY, Companion Diagnostic, diagnostic, MET, Rabbit Monoclonal Antibody, tyrosine kinase inhibitor

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Monoclonal Antibodies and Immunoconjugates Directed to the Non-ShedPortion (“Stalk”) of Mesothelin are Excellent Candidates for Developing Therapeutic Agents

Abstract: Human mesothelin is overexpressed by various cancers such as synovial sarcoma, mesothelioma, and ovarian, lung, esophageal, and gastric cancers. This selective expression on certain cancers suggests that mesothelin is an excellent target for anticancer therapeutics. However, a large fragment (“the shed portion”) of mesothelin is constantly...

Published: 5/21/2024 | Inventor(s): Ira Pastan, Masanori Onda, Tapan Bera, Mitchell Ho

Keywords(s): ANTIBODY, CANCER, CAR, chimeric antigen receptor, diagnostic, IMMUNOCONJUGATES, IMMUNOTOXINS, MESOTHELIN, Pastan, therapeutic

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Methods for Single Cell Analysis of the Epigenome, Transcriptome, and Genome

Abstract: There are currently no methodologies that allow for epigenome, genome and transcriptome analysis all in a single cell. In addition, there are currently no methodologies that permit repeating the results of these analyses on the same single cells. Scientists at the National Cancer Institute (NCI) Laboratory of Cellular Oncology have developed...

Published: 4/8/2024 | Inventor(s): Giovanna Tosato, Hidetaka Ohnuki

Keywords(s): diagnostic, Epigenomic, Genomic, RESEARCH TOOL, Single Cell Analysis, Tosato, Transcriptomic

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

SLCO1B3 Genotyping to Predict a Survival Prognosis of Prostate Cancer

Abstract: Steroid hormones have been implicated to play a fundamental role in the pathogenesis of prostate cancer. Polymorphisms in the genes that code for enzymes, or hormones involved in androgen regulatory pathway, reportedly influence risk for developing prostate cancer. Since many membrane transporters are modulators of steroid hormones absorption...

Published: 4/8/2024 | Inventor(s): William Figg, Alex Sparreboom, Douglas Price, Akinobu Hamada

Keywords(s): Androgen-directed Therapy, Biomarkers, diagnostic, Figg, genetic markers, Genomics, Hormone-Refractory, personalized medicine, predictive markers, prognostic, PROSTATE, SLCO1B3

Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Diagnostics, TherapeuticArea > Oncology

Chimeric Antigen Receptors (CAR)-T Cells that Target the Non-Shed Portion of Mesothelin as a Therapeutic Agent

Abstract: Mesothelin (MSLN) is an excellent target for antibody-based therapies of cancer because of its high expression in many malignancies but lack of expression on essential normal tissues. Unfortunately, a large fragment of MSLN is shed from cancer cells, causing the currently available anti-MSLN antibodies (and immunoconjugates thereof) which...

Published: 5/21/2024 | Inventor(s): Ira Pastan, Xiu Fen Liu, Tapan Bera, Masanori Onda, Mitchell Ho

Keywords(s): ANTIBODY, Bispecific T-cell engager, BITE, CANCER, CAR, chimeric antigen receptor, diagnostic, Immunotherapy, MESOTHELIN, Mesothelioma, Pastan, therapeutic

Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing

Gene-based Diagnostic Predicts Patient Response to Cancer Immunotherapy

Abstract: Immunotherapy is a promising method of treating cancer that leverages the immune system to promote tumor rejection. However, certain somatic mutations in cancer cells confer resistance to T cell-mediated cytolysis. To improve the effectiveness of immunotherapies for cancer, there exists a need to prospectively identify patients who are most...

Published: 9/13/2024 | Inventor(s): Shashankkumar Patel, Nicholas Restifo

Keywords(s): CRISPR, diagnostic, Gene, Immunotherapy, T-cell, tumor

Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Ratio Based Biomarkers for the Prediction of Cancer Survival

Abstract: The AKT pathway plays a key role in the regulation of cellular survival, apoptosis, and protein translation and has been shown to have prognostic significance in a number of cancers. Recently, the inventors have identified several functions of the AKT pathway in certain cancers, such as extrahepatic cholangiocarcinoma (EHCC). The NCI seeks...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Joon-Yong Chung, Udayan Guha

Keywords(s): AKT pathway, diagnostic, extrahepatic cholangiocarcinoma, prognostic

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Diagnostics, TherapeuticArea > Oncology

Automated Cancer Diagnostic Tool of Detecting, Quantifying and Mapping Mitotically-Active Proliferative Cells in Tumor Tissue Histopathology Whole-Slide Images

Abstract: Cancer diagnosis is based on the assessment of patient biopsies to determine the tumor type, grade, and stage of malignancy. The proliferative potential of tumors correlates to their growth and metastasis. Visually identifying and quantifying mitotic figures (MF) in cancer biopsy tissue can be used as a surrogate for proliferative activity...

Published: 5/23/2024 | Inventor(s): Robert Simpson, Stephen Hewitt, Shelley Hoover, Munish Puri

Keywords(s): Cancer Biopsy, diagnostic, Hewitt, HS, IHC, Immunohistochemistry, MF, Mitotic Figure, Mitotic Hotspots, Simpson, Tissue Histopathology

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Software / Apps

A Rabbit Anti-pT1989 ATR Monoclonal Antibody for Use in Immunoassays

Abstract: Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is essential for regulating DNA damage checkpoints during the cell cycle. ATR, is phosphorylated at threonine 1989 site (T1989) in response to DNA damage and ATR activation leads to activation of downstream substrates, signaling cascades and cell cycle arrest. ATR is a potential...

Published: 4/8/2024 | Inventor(s): Thomas Pfister, Allison Marrero, Ralph Parchment, James Doroshow, Robert Kinders

Keywords(s): ANTIBODY, assay, Ataxia telangiectasia mutated and Rad3-related kinase, CANCER, diagnostic, DNA checkpoint, monoclonal

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics

Prognostic Biomarkers for Patients with Early Stage Lung Cancer

Abstract: Surgery is the standard care for patients with stage I lung cancer. Despite successful surgery, 20-30% of patients will relapse. Chemotherapy can improve patient survival; however, it is controversial if early stage cancer patients should be treated with chemotherapy since, for many cases, it will harm quality of life with little therapeutic...

Published: 4/8/2024 | Inventor(s): Curtis Harris, Aaron Schetter, Ichiro Akagi, Hirokazu Okayama

Keywords(s): Biomarkers, diagnostic, lung cancer, prognostic assay

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics

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