Search Results - biomarkers

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SLCO1B3 Genotyping to Predict a Survival Prognosis of Prostate Cancer

Abstract: Steroid hormones have been implicated to play a fundamental role in the pathogenesis of prostate cancer. Polymorphisms in the genes that code for enzymes, or hormones involved in androgen regulatory pathway, reportedly influence risk for developing prostate cancer. Since many membrane transporters are modulators of steroid hormones absorption...

Published: 4/8/2024 | Inventor(s): William Figg, Alex Sparreboom, Douglas Price, Akinobu Hamada

Keywords(s): Androgen-directed Therapy, Biomarkers, diagnostic, Figg, genetic markers, Genomics, Hormone-Refractory, personalized medicine, predictive markers, prognostic, PROSTATE, SLCO1B3

Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Diagnostics, TherapeuticArea > Oncology

Exo-Clean Technology for Purifying Extracellular Vesicle Preparations from Contaminants

Abstract: Extracellular Vesicles (EVs), including exosomes and microvesicles, are nanometer-sized membranous vesicles that can carry different types of cargos, such as proteins, nucleic acids and metabolites. EVs are produced and released by most cell types. They act as biological mediators for intercellular communication via delivery of their cargos....

Published: 8/14/2024 | Inventor(s): Jennifer Jones, Jay Berzofsky, Joshua Welsh, Katherine McKinnon

Keywords(s): Affinity, Biomarkers, CHROMATOGRAPHIC, EVs, Exo-Clean, Exosomes, Extracellular Vesicles, High-throughput, Jones, Microvesicles, purification, Resin

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, TherapeuticArea > Immunology

Prognostic Biomarkers for Patients with Early Stage Lung Cancer

Abstract: Surgery is the standard care for patients with stage I lung cancer. Despite successful surgery, 20-30% of patients will relapse. Chemotherapy can improve patient survival; however, it is controversial if early stage cancer patients should be treated with chemotherapy since, for many cases, it will harm quality of life with little therapeutic...

Published: 4/8/2024 | Inventor(s): Curtis Harris, Aaron Schetter, Ichiro Akagi, Hirokazu Okayama

Keywords(s): Biomarkers, diagnostic, lung cancer, prognostic assay

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics

Novel Human Islet Amyloid Polypeptides as Alzheimer’s Disease Biomarkers and Inhibitors of Amyloid Formation

Abstract: Over 34 million Americans are living with diabetes. An estimated 6.5 million Americans are living with Alzheimer’s disease (AD) and type 2 diabetes mellites (T2DM). Amyloidosis due to aggregation of amyloid-β is key pathogenic event in AD, whereas aggregation of mature islet amyloid polypeptide (IAPP37) in human islet leads to β-cell dysfunction....

Published: 5/23/2024 | Inventor(s): Qing Rong Liu, Min Zhu, Josephine Egan

Keywords(s): Ad, Age-Associated Disease, Alzheimer’s Disease, Amyloidosis, Amyloids, Biomarkers, DIABETES, IAPP, Islet Amyloid Polypeptide Isoforms, Liu, National Institute on Aging, NIA, PEPTIDYL

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Biomarker for Predicting Taxane Chemotherapy Outcome

Abstract: Over the past decades, taxanes such as paclitaxel and docetaxel have emerged as effective chemotherapy agents for breast cancer and other malignancies. Taxanes are effective in many patients, however, not all patients benefit from this type of chemotherapy. A significant need remains for a means of predicting clinical outcome from taxane-based...

Published: 4/8/2024 | Inventor(s): Sherry Yang, Sandra Swain

Keywords(s): APOPTOSIS, Biomarkers, Docetaxel, Immunohistochemistry, PACLITAXEL, pAkt, taxane

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Oncology

Methods of Determining Homeostatic Perturbations

Abstract: Biological homeostasis is a state of steady internal, physical, and chemical conditions maintained by a living organism observed at the cellular level. Biological homeostasis can vary in order to alter the cellular physical and chemical conditions. Thus, it acts as a mechanism to define the physiological state of cellular activity; for instance...

Published: 4/8/2024 | Inventor(s): Rea Ravin, Nathan Williamson, Teddy Cai, Peter Basser

Keywords(s): Basser, Biomarkers, Central Nervous System, CNS, functional imaging, HOMEOSTASIS, Magnetic Resonance Imaging, MRI, NICHD, NMR, Nuclear Magnetic Resonance, r, Steady-state, The Eunice Kennedy Shriver National Institute of Child Healt

Category(s): TherapeuticArea > Oncology, TherapeuticArea > Neurology, Application > Diagnostics, Collaboration Sought > Licensing

MADCO-Accelerated Multidimensional Diffusion MRI

Abstract: Although multidimensional diffusion/relaxation NMR experiments are widely used in materials sciences and engineering applications, preclinical and clinical MRI applications of these techniques were not feasible. Moreover, higher-field MRI scanners posed another obstacle to translation of this NMR method. Their specific absorption rate (SAR)...

Published: 4/8/2024 | Inventor(s): Peter Basser, Dan Benjamini

Keywords(s): Basser, Biomarkers, Diffusion MRI, IMAGING, Marginal-Distributions, MRI, MRI diagnostic, Multidimensional-NMR, NMR-Spectroscopy, Relaxometry Diffusometry, T1, T2

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Diagnostics

Lymphatic Filariasis Biomarkers for Detection and Surveillance

Lymphatic filariasis (elephantiasis; LF) is a neglected tropical disease that affects over 120 million people throughout the tropics and subtropics of Asia, Africa, the Western Pacific, and parts of the Caribbean and South America. LF results from infection with the filarial parasites Wuchereria bancrofti or Brugia malayi. Current methods of confirming...

Published: 4/8/2024 | Inventor(s): Sasisekha Bennuru, Thomas Nutman

Keywords(s): 2IXXXX, 2XXXXX, Biomarkers, Detection, Filariasis, Lymphatic, Surveillance

Category(s):

Serum Protein Biomarkers that Predict the Response to Liver Directed Therapy in Methymalonic Acidemia (MMA) and Propionic Acidemia (PA)

Isolated Methylmalonic Acidemia (MMA) comprises a relatively common and heterogeneous group of inborn errors of metabolism. The most common cause of isolated MMA is genetic deficiency of the enzyme methylmalonyl-coA mutase (MUT), which, unfortunately for the affected patients, is also the most clinically severe. NHGRI scientist have discovered biomarkers...

Published: 7/25/2024 | Inventor(s): Eirini (Irini) Manoli, Charles Venditti

Keywords(s): Acidemia, Biomarkers, Directed, liver, Methymalonic, MMA, PREDICT, Protein, RESPONSE, SERUM, That, THERAPY, VPXXXX, WBXXXX, WIXXXX, XCXXXX, XEXXXX

Category(s): Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Oncology, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Infectious Disease

Non-invasive Isotopic Biomarkers that Predict the Response to Liver Directed Therapy in Methymalonic Acidemia (MMA) and Propionic Acidemia (PA)

Published: 7/25/2024 | Inventor(s): Eirini (Irini) Manoli, Charles Venditti

Keywords(s): Acidemia, Biomarkers, Directed, ISOTOPIC, liver, Methymalonic, MMA, NON-INVASIVE, PREDICT, RESPONSE, That, THERAPY, VPXXXX, WFXXXX, WIXXXX, XCXXXX

Category(s): Application > Occupational Safety and Health, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Dental, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology

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