Search Results - mri

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Time Efficient Multi-Pulsed Field Gradient (mPFG) MRI Without Concomitant Gradient Field Artifacts

Summary: The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research co-development partners and/or licensees for the development of diffusion tensor distribution MR imaging (DTD-MRI) in assessing disease (e.g., cancer), normal and abnormal developmental processes, degeneration and trauma in the brain...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Peter Basser, Michal Komlosh, Magdoom Mohamed Kulam Najmudeen

Keywords(s): Basser, Diffusion Tensor Distribution MR Imaging, DTI, Eunice Kennedy Shriver National Institute of Child Health an, Komlosh, Magnetic Resonance Imaging, mPFG, MRI, Multi-Pulsed Field Gradient, Najmudeen, NICHD

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Immunology

Denoising of Dynamic Magnetic Resonance Spectroscopic Imaging Using Low Rank Approximations in the Kinetic Domain

Summary: The scientists seek co-development parties and/or licensees for a method for measuring low-abundance metabolites in vivo. Description of Technology: Accurate measurement of low metabolite concentrations produced by medically important enzymes is commonly obscured by noise during magnetic resonance imaging (MRI). Measuring the turnover rate...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Jeffery Brender, Kazutoshi Yamamoto, Jeeva Munasinghe, Shun Kishimoto, Hellmut Merkle, Murali Cherukuri, James Mitchell

Keywords(s): 13C imaging, Brender, Denoising, DNP, Dynamic Nuclear Polarization, Glucose Metabolism, Low Metabolite Concentration, Magnetic Resonance Imaging, Metabolic Enzymes, MRI, Software Plugin, SPECTROSCOPIC

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Oncology

Tamperless Tensor Elastography Imaging

Summary: The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research co-development partners and/or licensees for the development of tamper-less tensor elastography imaging in assessing disease (e.g., cancer), normal and abnormal developmental processes, degeneration and trauma in the brain and other soft...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Peter Basser, Magdoom Mohamed Kulam Najmudeen

Keywords(s): Alzheimer’s Disease, Anisotropy, Basse, brain, CANCER, Elasticity Tensor, Elastography, Eunice Kennedy Shriver National Institute of Child Health an, Magnetic Resonance Imaging, MRI, Najmudeen, NICHD, TBI, TRAUMA, Traumatic Brain Injury

Category(s): TherapeuticArea > Neurology, Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

MRI-Based Method for Characterizing Axonal Microstructure in Traumatic Brain Injury

Abstract: Neurites of the central nervous system can be conceptualized as cylindrical pores with finite lengths and radii. In response to physical trauma, axons may assume a “beaded” morphology which alters their ability to conduct electrical impulses, impairing brain function. These microstructural changes are thought to underlie some of the cognitive...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Peter Basser, Dan Benjamini, Michal Komlosh

Keywords(s): Magnetic Resonance Imaging, MRI, MRI diagnostic, Neurites, Peripheral Nervous System, PNS, TBI, Traumatic Brain Injury

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology

Methods of Determining Homeostatic Perturbations

Description of Technology: Biological homeostasis is a state of steady internal, physical, and chemical conditions maintained by a living organism observed at the cellular level. Biological homeostasis can vary in order to alter the cellular physical and chemical conditions. Thus, it acts as a mechanism to define the physiological state of cellular...

Published: 4/16/2026 | Updated: 8/2/2023 | Inventor(s): Rea Ravin, Nathan Williamson, Teddy Cai, Peter Basser

Keywords(s): Basser, Biomarkers, Central Nervous System, CNS, functional imaging, HOMEOSTASIS, Magnetic Resonance Imaging, MRI, NICHD, NMR, Nuclear Magnetic Resonance, r, Steady-state, The Eunice Kennedy Shriver National Institute of Child Healt

Category(s): TherapeuticArea > Oncology, TherapeuticArea > Neurology, Application > Diagnostics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration

MADCO-Accelerated Multidimensional Diffusion MRI

Abstract: Although multidimensional diffusion/relaxation NMR experiments are widely used in materials sciences and engineering applications, preclinical and clinical MRI applications of these techniques were not feasible. Moreover, higher-field MRI scanners posed another obstacle to translation of this NMR method. Their specific absorption rate (SAR)...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Peter Basser, Dan Benjamini

Keywords(s): Basser, Biomarkers, Diffusion MRI, IMAGING, Marginal-Distributions, MRI, MRI diagnostic, Multidimensional-NMR, NMR-Spectroscopy, Relaxometry Diffusometry, T1, T2

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Diagnostics

Quantitative In Vivo Methods for Measuring Brain Networks

Abstract: The pattern or latency connectome was hypothesized to change in physiological development and disease. For example, in amyotrophic lateral sclerosis (ALS), large diameter axons are damaged selectively – while in autism, small-diameter axons may be over-expressed. These anatomical changes are expected to alter the latency connectome or pattern...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Peter Basser

Keywords(s): Axon diameter distribution, connectome, DTI Tractography, Magnetic Resonance Imaging, MRI, MRI diagnostic

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Diagnostics

Multidimensional MRI Signature for Specific Detection of Traumatic Brain Injury In Vivo

Summary: The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research co-development partners and/or licensees for the development of multidimensional MRI-based methods. Description of Technology: Traumatic brain injury (TBI) represents a major medical, social and economic concern worldwide due to significant...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Dan Benjamini, Peter Basser, Diego Iacono

Keywords(s): Amyloid Precursor Protein, Be, DAI, Diffuse Axonal Injury, Eunice Kennedy Shriver National Institute of Child Health an, Magnetic Resonance Imaging, MRI, MULTIDIMENSIONAL, NICHD, TAI, TBI, Traumatic Axonal Injury, Traumatic Brain Injury

Category(s): TherapeuticArea > Neurology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics

Systems and Devices for Training and Imaging an Awake Test Animal

Abstract: Typical MRI imaging sessions can last over 45 minutes and depend on the subject remaining still during the procedure for accurate imaging. In particular, animals being imaged, such as rodents (rats) in an awakened state, are not readily compliant with the restricted movement required when being imaged. Current techniques for imaging awake...

Published: 8/6/2025 | Updated: 8/2/2023 | Inventor(s): Hanbing Lu, Yihong Yang, Elliot Stein

Keywords(s): Imaging awake rodents, MRI

Category(s): Application > Medical Devices, TherapeuticArea > Neurology, Collaboration Sought > Licensing, Application > Non-Medical Devices

Novel Magnetic Resonance Spectroscopy (MRS) Technique to Quantify Brain Metabolites

With respect to quantification of metabolites in the brain, conventional methods of magnetic resonance spectroscopy (MRS) yield results that are highly variable and highly dependent on the sequence type being applied. This invention describes a novel MRS technique that involves preparing longitudinal steady states at different flip angles using trains...

Published: 10/28/2024 | Updated: 12/6/2022 | Inventor(s): Jun Shen, Linqing Li

Keywords(s): AAXXXX, DRIVEN, IMAGING, ImagingMRI, LINEAR, METABOLITE, MRI, NCXXXX, Probing, QUANTIFICATION, Relaxation, RF, States, Steady, VCXXXX, VEXXXX, Vivo, VNXXXX, WBXXXX, XFXXXX, YAXXXX, YDXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Neurology, TherapeuticArea > Psychiatry/Mental Health, Application > Non-Medical Devices, TherapeuticArea > Oncology, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, Application > Research Materials

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