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Device for Simulating Explosive Blast and Imaging Biological Specimens

Abstract: Traumatic brain injury (TBI) is a major health problem. Between 3.2 and 5.3 million people live with long-term disabilities resulting from TBI, and thus, contribute to the need to develop therapies that treat TBI-induced cellular damage. Researchers at the National Institute of Child Health and Human Development (NICHD) have developed a device...

Published: 4/8/2024 | Inventor(s): Rea Ravin, Paul Blank, Alex Steinkamp, Joshua Zimmerberg, Sergey Bezrukov, Kim Lee Mcafee

Keywords(s): Central Nervous System, CNS, explosive blast, National Institute of Child Health and Human Development, NICHD, SIMULATOR, TBI, Traumatic Brain Injury, Zimmerberg

Category(s): Application > Non-Medical Devices, Collaboration Sought > Collaboration, Application > Medical Devices, TherapeuticArea > Neurology, Collaboration Sought > Licensing

Therapeutics for Neurodegenerative Disorders and Cancer Using Lenalidomide Analogs

Abstract: Inflammatory processes associated with the over-production of tumor necrosis-alpha (TNF-alpha), a potent activator of the immune system accompany numerous neurodegenerative diseases. TNF-alpha has been validated as a drug target with the development of the inhibitors Enbrel and Remicade (fusion antibodies) as prescription medications. Both,...

Published: 4/8/2024 | Inventor(s): Nigel Greig, Weiming Luo, David Tweedie, Harold Holloway, Qian-sheng Yu, Edward Goetzl

Keywords(s): CNS, Holloway, Immunomodulatory Agents, Inflammation, Lenalidomide, National Institute on Aging, Neurodegenerative Disorders, NIA, THALIDOMIDE, TNF-alpha, Tumor Necrosis-alpha

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Isotropic Generalized Diffusion Tensor MRI

Abstract: Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring...

Published: 4/8/2024 | Inventor(s): Alexandru Avram, Peter Basser

Keywords(s): ADC, Basser, Central Nervous System, CNS, diffusion, Diffusion Weighted Images, Distribution, DWI, Fetus, High-Order Tensor, Image Analysis, Isotropic Diffusion Tensor Imaging, mADC, Mean Apparent Diffusion Coefficient, MRI Pulse Sequences, PATHOLOGY, Peripheral Nervous System, Placenta, PNS, STROKE, TRACE, Whole-Body

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Software / Apps

Methods of Determining Homeostatic Perturbations

Abstract: Biological homeostasis is a state of steady internal, physical, and chemical conditions maintained by a living organism observed at the cellular level. Biological homeostasis can vary in order to alter the cellular physical and chemical conditions. Thus, it acts as a mechanism to define the physiological state of cellular activity; for instance...

Published: 4/8/2024 | Inventor(s): Rea Ravin, Nathan Williamson, Teddy Cai, Peter Basser

Keywords(s): Basser, Biomarkers, Central Nervous System, CNS, functional imaging, HOMEOSTASIS, Magnetic Resonance Imaging, MRI, NICHD, NMR, Nuclear Magnetic Resonance, r, Steady-state, The Eunice Kennedy Shriver National Institute of Child Healt

Category(s): TherapeuticArea > Oncology, TherapeuticArea > Neurology, Application > Diagnostics, Collaboration Sought > Licensing