Search Results - national+institute+of+child+health+and+human+development

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Levonorgestrel Butanoate Formulation and Methods Relating Thereto

Abstract: This invention is a potential subcutaneous or intramuscular progestin-only, injectable contraceptive for women. Forty-five percent (45%) of pregnancies in the United States are unintended. In this group, one-third of reproductive age women are obese – increasing the risk of diabetes, hypertension and venous thromboembolism (VTE). All these...

Published: 4/8/2024 | Inventor(s): Min Lee, Diana Blithe, Jia-Hwa Fang, Eduardo Ruiz, Ken Chen

Keywords(s): Blithe, CONTRACEPTIVE, INJECTABLE, LB, Lee, Levonorgestrel, Levonorgestrel Butanoate, LNG, National Institute of Child Health and Human Development, NICHD, Steroidal Progestin

Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Reproductive Health

Device for Simulating Explosive Blast and Imaging Biological Specimens

Abstract: Traumatic brain injury (TBI) is a major health problem. Between 3.2 and 5.3 million people live with long-term disabilities resulting from TBI, and thus, contribute to the need to develop therapies that treat TBI-induced cellular damage. Researchers at the National Institute of Child Health and Human Development (NICHD) have developed a device...

Published: 4/8/2024 | Inventor(s): Rea Ravin, Paul Blank, Alex Steinkamp, Joshua Zimmerberg, Sergey Bezrukov, Kim Lee Mcafee

Keywords(s): Central Nervous System, CNS, explosive blast, National Institute of Child Health and Human Development, NICHD, SIMULATOR, TBI, Traumatic Brain Injury, Zimmerberg

Category(s): Application > Non-Medical Devices, Collaboration Sought > Collaboration, Application > Medical Devices, TherapeuticArea > Neurology, Collaboration Sought > Licensing

Improved Gene Therapy Vectors for the Treatment of Glycogen Storage Disease Type Ia (GSD-1a)

Abstract: GSD-Ia is an inherited disorder of metabolism associated with life-threatening hypoglycemia, hepatic malignancy, and renal failure caused by the deficiency of glucose-6-phosphatase-alpha (G6Pase-alpha or G6PC). Current therapy, which primarily consists of dietary modification, fails to prevent long-term complications in many patients, including...

Published: 4/8/2024 | Inventor(s): Janice Chou, Barry Byrne

Keywords(s): Chou, GSD-1a, hepatic malignancy, hyperlipidemia, hypoglycemia, National Institute of Child Health and Human Development, NICHD

Category(s): TherapeuticArea > Nephrology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology

Nandrolone 17 Beta-Carbonates

Abstract: The available options for male contraceptives are limited. Androgens are administered as part of hormone-based male contraception and have also been used in the treatment of hypogonadism and hormone replacement therapy HRT. Many synthetic androgens require an oil-based delivery vehicle and have limited durations of action. This technology...

Published: 7/1/2024 | Inventor(s): Richard Blye, Hyun Kim, Min Lee

Keywords(s): 19-nortestosterone, Androgenic Compounds, Blye, Male Contraceptive, Nandrolone, National Institute of Child Health and Human Development, NICHD

Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Reproductive Health

La Protein as a Novel Regulator of Osteoclastogenesis

Abstract: Millions of patients in the United States are afflicted by a host of bone diseases caused by osteoclast (specialized calls arising from the macrophage/monocyte lineage) dysfunction. Diseases include Paget’s disease, osteoporosis, fibrous dysplasia and osteolytic bone metastasis. The current standard of care for these diseases uses broad-spectrum...

Published: 4/8/2024 | Inventor(s): Leonid Chernomordik, Evgenya Leikina, Jarred Whitlock

Keywords(s): Chernomordik, La Protein, Lupus Autoantigen Protein, National Institute of Child Health and Human Development, NICHD, Osteoclast Fusion, Osteoclastogenesis

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics