Search Results - nichd

16 Results

Sort By:

Levonorgestrel Butanoate Formulation and Methods Relating Thereto

Description of Technology: This invention is a potential subcutaneous or intramuscular progestin-only, injectable contraceptive for women. Forty-five percent (45%) of pregnancies in the United States are unintended. In this group, one-third of reproductive age women are obese – increasing the risk of diabetes, hypertension and venous thromboembolism...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Min Lee, Diana Blithe, Jia-Hwa Fang, Eduardo Ruiz, Ken Chen

Keywords(s): Blithe, CONTRACEPTIVE, INJECTABLE, LB, Lee, Levonorgestrel, Levonorgestrel Butanoate, LNG, National Institute of Child Health and Human Development, NICHD, Steroidal Progestin

Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Reproductive Health

Device for Simulating Explosive Blast and Imaging Biological Specimens

Abstract: Traumatic brain injury (TBI) is a major health problem. Between 3.2 and 5.3 million people live with long-term disabilities resulting from TBI, and thus, contribute to the need to develop therapies that treat TBI-induced cellular damage. Researchers at the National Institute of Child Health and Human Development (NICHD) have developed a device...

Published: 4/14/2026 | Updated: 8/2/2023 | Inventor(s): Rea Ravin, Paul Blank, Alex Steinkamp, Joshua Zimmerberg, Sergey Bezrukov, Kim Lee Mcafee

Keywords(s): Central Nervous System, CNS, explosive blast, National Institute of Child Health and Human Development, NICHD, SIMULATOR, TBI, Traumatic Brain Injury, Zimmerberg

Category(s): Application > Non-Medical Devices, Collaboration Sought > Collaboration, Application > Medical Devices, TherapeuticArea > Neurology, Collaboration Sought > Licensing

Treatment of GPR101-Related, Growth Hormone-Related Disorders Such as Gigantism, Dwarfism or Acromegaly

Abstract: Microduplications of the GPR101 gene (located on chromosome Xq26.3 and encodes a G-protein coupled receptor) can result in an excess of growth hormone causing gigantism, that has an onset in early childhood. It is also associated with the growth of sporadic growth hormone producing adenomas in some patients with acromegaly. Current therapies...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Adrian Daly, Albert Beckets, Fabio Faucz, Giampaolo Trivellin, Constantine Stratakis

Keywords(s): acromegaly, Dwarfism, Eunice Kennedy Shriver National Institute of Child Health an, Gigantism, GPR101, growth hormone regulation, NICHD

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Endocrinology

Enhanced Antigen Reactivity of Immune Cells Expressing a Mutant Non-Signaling CD3 Zeta Chain

Summary: Researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development are highly motivated in seeking licensing and/or collaboration partners to develop therapeutic cell populations arising out of these technologies. An ideal partner would enter into both a Cooperative Research and Development Agreement (CRADA)...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Paul Love, Guillaume Gaud, Christian Hinrichs, John Davies

Keywords(s): CD3, Davies, Eunice Kennedy Shriver National Institute of Child Health an, Gaud, Hinrichs, Immuno-receptor Tyrosine-based Activation Motif, Immunotherapy, ITAM, Love, National Cancer Institute, Nci, NICHD, T Cell Receptor, TCR, Zeta Chain

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology

A Novel Transgenic Zebrafish Line Reporting Dynamic Epigenetic Changes

Abstract: Currently, there is no other whole-animal reporter for epigenetic regulation established in any vertebrate. The inventors generated this novel zebrafish line using a transgene construct containing dazl gene silencing sequences (CpG island) fused to a destabilized GFPd2 gene driven by the ubiquitously expressing ef1alpha promoter. The resulting...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Aniket Gore, Brant Weinstein

Keywords(s): Development, DNA Methylation, Epigenetic Silencing, Eunice Kennedy Shriver National Institute of Child Health an, GFPd2, NICHD, Tissue-specific Expression, Weinstein, Zebrafish

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

Autophagy Modulators For Use in Treating Cancer

Abstract: Cancer cells can upregulate autophagy – cell destruction – as a response to chemotherapy. Investigators in Dr. Melvin DePamphilis’ laboratory at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) have shown that compounds identified by screening a library of compounds blocks autophagy in some cancer...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Melvin DePamphilis, Gaurav Sharma, Marc Ferrer-Alegre, Juan Marugan, Ajit Roy

Keywords(s): BRAF Mutation, Depamphilis, Eunice Kennedy Shriver National Institute of Child Health an, Inhibition of Autophagy, NICHD, WX8

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Improved Gene Therapy Vectors for the Treatment of Glycogen Storage Disease Type Ia (GSD-1a)

Summary: NICHD is seeking licensees for development of an adeno-associated viral (AAV) vectors for the treatment of glycogen storage disease type Ia (GSD-Ia). Description of Technology: GSD-Ia is an inherited disorder of metabolism associated with life-threatening hypoglycemia, hepatic malignancy, and renal failure caused by the deficiency of glucose-6-phosphatase-alpha...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Janice Chou, Barry Byrne

Keywords(s): Chou, GSD-1a, hepatic malignancy, hyperlipidemia, hypoglycemia, National Institute of Child Health and Human Development, NICHD

Category(s): TherapeuticArea > Nephrology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology

Time Efficient Multi-Pulsed Field Gradient (mPFG) MRI Without Concomitant Gradient Field Artifacts

Summary: The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research co-development partners and/or licensees for the development of diffusion tensor distribution MR imaging (DTD-MRI) in assessing disease (e.g., cancer), normal and abnormal developmental processes, degeneration and trauma in the brain...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Peter Basser, Michal Komlosh, Magdoom Mohamed Kulam Najmudeen

Keywords(s): Basser, Diffusion Tensor Distribution MR Imaging, DTI, Eunice Kennedy Shriver National Institute of Child Health an, Komlosh, Magnetic Resonance Imaging, mPFG, MRI, Multi-Pulsed Field Gradient, Najmudeen, NICHD

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Immunology

Monomeric and Oligomeric Compounds as Contraceptives and Endocrine Therapeutics

Summary: NICHD is seeking research co-development partners and/or licensees for development of this invention as a male contraceptive. Description of Technology: The options for male contraceptives are limited. Research is ongoing to develop a male contraceptive based on hormonal activity. Testosterone is one of the hormones necessary in producing...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Min Lee, Diana Blithe, Pranab Gupta, Bashir Kaskar, Ming-Teh Lin

Keywords(s): Blithe, CONTRACEPTIVE, Estrogenic Activity, Eunice Kennedy Shriver National Institute of Child Health an, Lee, Male Contraceptive, MONOMERIC, NCE, New Chemical Entity, NICHD, OLIGOMERIC

Category(s): Application > Therapeutics, TherapeuticArea > Reproductive Health, TherapeuticArea > Endocrinology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Tamperless Tensor Elastography Imaging

Summary: The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research co-development partners and/or licensees for the development of tamper-less tensor elastography imaging in assessing disease (e.g., cancer), normal and abnormal developmental processes, degeneration and trauma in the brain and other soft...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Peter Basser, Magdoom Mohamed Kulam Najmudeen

Keywords(s): Alzheimer’s Disease, Anisotropy, Basse, brain, CANCER, Elasticity Tensor, Elastography, Eunice Kennedy Shriver National Institute of Child Health an, Magnetic Resonance Imaging, MRI, Najmudeen, NICHD, TBI, TRAUMA, Traumatic Brain Injury

Category(s): TherapeuticArea > Neurology, Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

1 2