Search Results - depamphilis

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Autophagy Modulators For Use in Treating Cancer

Abstract: Cancer cells can upregulate autophagy – cell destruction – as a response to chemotherapy. Investigators in Dr. Melvin DePamphilis’ laboratory at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) have shown that compounds identified by screening a library of compounds blocks autophagy in some cancer...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Melvin DePamphilis, Gaurav Sharma, Marc Ferrer-Alegre, Juan Marugan, Ajit Roy

Keywords(s): BRAF Mutation, Depamphilis, Eunice Kennedy Shriver National Institute of Child Health an, Inhibition of Autophagy, NICHD, WX8

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Therapeutics Against Pathogenic Coronaviruses

Summary: Researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development are highly motivated in seeking research co-development partners and/or licensees to further develop and commercialize PIKfyve phosphatidyl linositol kinase inhibitors for the treatment of pathogenic coronaviruses. An ideal partner would enter...

Published: 4/23/2026 | Updated: 8/2/2023 | Inventor(s): Melvin DePamphilis, Matthew Frieman, Arup Chakraborty

Keywords(s): CORONAVIRUS, COVID-19, Depamphilis, Eunice Kennedy Shriver National Institute of Child Health an, Infectious Diseases, MER-CoV, NICHD, PIKfyve Phosphatidyl Linositol Kinase Inhibitors, SARS-CoV, SARS-CoV-2, virus

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease