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A Novel Transgenic Zebrafish Line Reporting Dynamic Epigenetic Changes

Abstract: Currently, there is no other whole-animal reporter for epigenetic regulation established in any vertebrate. The inventors generated this novel zebrafish line using a transgene construct containing dazl gene silencing sequences (CpG island) fused to a destabilized GFPd2 gene driven by the ubiquitously expressing ef1alpha promoter. The resulting...

Published: 4/8/2024 | Inventor(s): Aniket Gore, Brant Weinstein

Keywords(s): Development, DNA Methylation, Epigenetic Silencing, Eunice Kennedy Shriver National Institute of Child Health an, GFPd2, NICHD, Tissue-specific Expression, Weinstein, Zebrafish

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology