Search Results - peter+basser

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Time Efficient Multi-Pulsed Field Gradient (mPFG) MRI Without Concomitant Gradient Field Artifacts

Abstract: Measuring and mapping nervous tissue microstructure noninvasively is a long sought-after goal in neuroscience. Clinically, several neuropathologies such as cancer and stroke, are associated with changes in tissue microstructure. Diffusion tensor imaging (DTI), which models diffusion anisotropy, is an ideal imaging modality to elucidate these...

Published: 4/8/2024 | Inventor(s): Peter Basser, Michal Komlosh, Magdoom Mohamed Kulam Najmudeen

Keywords(s): Basser, Diffusion Tensor Distribution MR Imaging, DTI, Eunice Kennedy Shriver National Institute of Child Health an, Komlosh, Magnetic Resonance Imaging, mPFG, MRI, Multi-Pulsed Field Gradient, Najmudeen, NICHD

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Immunology

Tamperless Tensor Elastography Imaging

Abstract: Measuring and mapping nervous tissue microstructure noninvasively is a long sought-after goal in neuroscience. Several neuropathologies – such as cancer and stroke – are associated with changes in tissue microstructure. Changes in material properties, such as stiffness, represent a sensitive measure of underlying changes in tissue architecture,...

Published: 4/8/2024 | Inventor(s): Peter Basser, Magdoom Mohamed Kulam Najmudeen

Keywords(s): Alzheimer’s Disease, Anisotropy, Basse, brain, CANCER, Elasticity Tensor, Elastography, Eunice Kennedy Shriver National Institute of Child Health an, Magnetic Resonance Imaging, MRI, Najmudeen, NICHD, TBI, TRAUMA, Traumatic Brain Injury

Category(s): TherapeuticArea > Neurology, Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Composite Gels and Methods of their Use in Tissue Repair, Drug Delivery, and as Implants

Abstract: Gel materials, particularly hydrogels, typically lose their mechanical strength and stiffness as they swell. This property limits their use in both biological (e.g., cartilage and ECM repair) and non-biological (e.g., sealant) applications. Innovative materials in both medical and non-medical application areas are sorely needed. Recent innovations...

Published: 4/8/2024 | Inventor(s): Ferenc Horkay, Peter Basser

Keywords(s): Basser, Cartilage, Composite, Drug Delivery, Gel, Horkay, Hydrogels, IMPLANTS, MATRIX, polymer, sealants, Tissue, Tissue Repair

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices, Collaboration Sought > Materials Available, TherapeuticArea > Dermatology

MRI-Based Method for Characterizing Axonal Microstructure in Traumatic Brain Injury

Abstract: Neurites of the central nervous system can be conceptualized as cylindrical pores with finite lengths and radii. In response to physical trauma, axons may assume a “beaded” morphology which alters their ability to conduct electrical impulses, impairing brain function. These microstructural changes are thought to underlie some of the cognitive...

Published: 4/8/2024 | Inventor(s): Peter Basser, Dan Benjamini, Michal Komlosh

Keywords(s): Magnetic Resonance Imaging, MRI, MRI diagnostic, Neurites, Peripheral Nervous System, PNS, TBI, Traumatic Brain Injury

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology

Isotropic Generalized Diffusion Tensor MRI

Abstract: Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring...

Published: 4/8/2024 | Inventor(s): Alexandru Avram, Peter Basser

Keywords(s): ADC, Basser, Central Nervous System, CNS, diffusion, Diffusion Weighted Images, Distribution, DWI, Fetus, High-Order Tensor, Image Analysis, Isotropic Diffusion Tensor Imaging, mADC, Mean Apparent Diffusion Coefficient, MRI Pulse Sequences, PATHOLOGY, Peripheral Nervous System, Placenta, PNS, STROKE, TRACE, Whole-Body

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Software / Apps

Methods of Determining Homeostatic Perturbations

Abstract: Biological homeostasis is a state of steady internal, physical, and chemical conditions maintained by a living organism observed at the cellular level. Biological homeostasis can vary in order to alter the cellular physical and chemical conditions. Thus, it acts as a mechanism to define the physiological state of cellular activity; for instance...

Published: 4/8/2024 | Inventor(s): Rea Ravin, Nathan Williamson, Teddy Cai, Peter Basser

Keywords(s): Basser, Biomarkers, Central Nervous System, CNS, functional imaging, HOMEOSTASIS, Magnetic Resonance Imaging, MRI, NICHD, NMR, Nuclear Magnetic Resonance, r, Steady-state, The Eunice Kennedy Shriver National Institute of Child Healt

Category(s): TherapeuticArea > Oncology, TherapeuticArea > Neurology, Application > Diagnostics, Collaboration Sought > Licensing

MADCO-Accelerated Multidimensional Diffusion MRI

Abstract: Although multidimensional diffusion/relaxation NMR experiments are widely used in materials sciences and engineering applications, preclinical and clinical MRI applications of these techniques were not feasible. Moreover, higher-field MRI scanners posed another obstacle to translation of this NMR method. Their specific absorption rate (SAR)...

Published: 4/8/2024 | Inventor(s): Peter Basser, Dan Benjamini

Keywords(s): Basser, Biomarkers, Diffusion MRI, IMAGING, Marginal-Distributions, MRI, MRI diagnostic, Multidimensional-NMR, NMR-Spectroscopy, Relaxometry Diffusometry, T1, T2

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Diagnostics

Quantitative In Vivo Methods for Measuring Brain Networks

Abstract: The pattern or latency connectome was hypothesized to change in physiological development and disease. For example, in amyotrophic lateral sclerosis (ALS), large diameter axons are damaged selectively – while in autism, small-diameter axons may be over-expressed. These anatomical changes are expected to alter the latency connectome or pattern...

Published: 4/8/2024 | Inventor(s): Peter Basser

Keywords(s): Axon diameter distribution, connectome, DTI Tractography, Magnetic Resonance Imaging, MRI, MRI diagnostic

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Diagnostics

Multidimensional MRI Signature for Specific Detection of Traumatic Brain Injury In Vivo

Abstract: Traumatic brain injury (TBI) represents a major medical, social and economic concern worldwide due to significant mortality – especially among younger populations – and long-term disabilities. Various pathological brain lesions (e.g., intracerebral bleedings, necrotic-ischemic lesions, tissue avulsion) are produced by impacting mechanical...

Published: 4/8/2024 | Inventor(s): Dan Benjamini, Peter Basser, Diego Iacono

Keywords(s): Amyloid Precursor Protein, Be, DAI, Diffuse Axonal Injury, Eunice Kennedy Shriver National Institute of Child Health an, Magnetic Resonance Imaging, MRI, MULTIDIMENSIONAL, NICHD, TAI, TBI, Traumatic Axonal Injury, Traumatic Brain Injury

Category(s): TherapeuticArea > Neurology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics

Magnetic Resonance Specimen Evaluation Using Multiple Pulse Field Gradient Sequences

Abstract: Researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) developed an MRI-method that is based on the acquisition of multiple pulsed field gradient (m-PFG) rather than single-pulsed field gradient (s-PFG) MRI sequences. In particular, double PFG (dPFG) MRI sequences offer higher sensitivity...

Published: 4/8/2024 | Inventor(s): Peter Basser, Evren Ozarslan

Keywords(s): Axon diameter distribution, double PFG, d-PFG, MRI diagnostic, Multiple Pulsed Field Gradient

Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology

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