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Novel Fixative for Improved Biomolecule Quality from Paraffin-Embedded Tissue

Abstract: Tissues samples collected during medical procedures, such as biopsies, are used to diagnose a wide variety of diseases. Before diagnosis, patient samples are typically processed by fixation and paraffin embedding. This fixation/embedding process is used to preserve tissue morphology and histology for subsequent evaluation. Unfortunately, most...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Candice Perry, Joon-Yong Chung, Robert Star

Keywords(s): CULTURE, fixative, Histology, PARAFFIN, PATHOLOGY, Tissue

Category(s): Collaboration Sought > Licensing, Application > Medical Devices, TherapeuticArea > Oncology, Application > Non-Medical Devices

Composite Gels and Methods of their Use in Tissue Repair, Drug Delivery, and as Implants

Abstract: Gel materials, particularly hydrogels, typically lose their mechanical strength and stiffness as they swell. This property limits their use in both biological (e.g., cartilage and ECM repair) and non-biological (e.g., sealant) applications. Innovative materials in both medical and non-medical application areas are sorely needed. Recent innovations...

Published: 4/8/2024 | Inventor(s): Ferenc Horkay, Peter Basser

Keywords(s): Basser, Cartilage, Composite, Drug Delivery, Gel, Horkay, Hydrogels, IMPLANTS, MATRIX, polymer, sealants, Tissue, Tissue Repair

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices, Collaboration Sought > Materials Available, TherapeuticArea > Dermatology

A Specialized Tissue Collection Device for the Preservation and Transportation of Needle Biopsies

Abstract: The ability to hold and transport tissue, especially needle biopsies in a pre-defined and controlled environment is critical for the preservation of biopsy samples in downstream analytic applications. Currently, tissue specimens are placed in open containers with variable, poorly controlled solutions applied to them, often in less than sterile...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Robert Star, Hiroshi Kijoma, Jeffrey Hanson, Armando Filie, Russell Bandle

Keywords(s): COLLECTION, DEVICE, FIXATION, Hewitt, KIDNEY, liver, LUNG, Needle Biopsy, PANCREAS, PRESERVATION, STERILE, Storage, Tissue, Transportation

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Medical Devices, Collaboration Sought > Collaboration, Application > Non-Medical Devices

Enhanced Tissue Clearing Solution, Clearing-Enhanced 3D (Ce3D), Compatible with Advanced Fluorescence Microscopy Imaging

NIH immunologists have created a solution, Clearing-enhanced 3D (Ce3D), that can be used to make entire organs extremely transparent (top right panel). This allows the tissue to be imaged using advanced fluorescence microscopy techniques (bottom panel). Unlike current tissue clearing solutions, the Ce3D tissue clearing solution is robustly compatible...

Published: 7/25/2024 | Inventor(s): Michael Gerner, Weizhe Li, Ronald Germain

Keywords(s): 3D, AA3AXX, Ce3D:, Cellular, Clearing, Epitope, Fluorescence, histo-cytometry, IMAGING, imaging agent, Method, MICROSCOPY, REPORTER, Tissue

Category(s): Collaboration Sought > Collaboration

Live Tissue Imaging Gel

The National Heart Lung and Blood Institute (NHLBI), Laboratory of Cardiac Energetics, has created a gel with 0.3%-0.5% carbomer 940 which is easily used as an imaging immersion medium for confocal and two photon fluorescence emission microscopy and second harmonic generation imaging. This thick, but transparent, gel can be layered on tissue for microscopic...

Published: 4/8/2024 | Inventor(s): Robert Balaban

Keywords(s): AC3XXX, AC5XXX, ACXXXX, AXXXXX, Gel, IMAGING, Live, Tissue

Category(s): Collaboration Sought > Licensing