Search Results - microscopy

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Mitotic Figures Electronic Counting Application for Surgical Pathology

Abstract: Cancer diagnosis depends on the assessment of patient biopsies to determine tumor type, grading, and stage of malignancy. Pathologists visually review specimens and count mitotic figures (MF) in a variety of cancer types to help gauge aggressiveness, guide treatment, and inform patient prognosis. Current technology for recording MF counts...

Published: 5/23/2024 | Inventor(s): Robert Simpson, Munish Puri, Stephen Hewitt

Keywords(s): cell proliferation, COUNTING, ELECTRONIC, MATLAB, Matrix Laboratory, MF, MICROSCOPY, Mitotic Figures, PATHOLOGY, Simpson, SURGICAL

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Oncology

A New Class of Stable Heptamethine Cyanine Fluorophores and Biomedical Applications Thereof

Abstract: Heptamethine cyanines are among the most widely used near-IR fluorophores. The near-IR range (between about 650 nm and 900 nm) is very useful for imaging applications due to the absence of background autofluorescence. Despite extensive use, many of these fluorophores suffer from chemical instability. Specifically, most of the current and commonly...

Published: 4/8/2024 | Inventor(s): Martin Schnermann, Roger Nani, James Shaum

Keywords(s): Antibody labeling, DYE, Fluorescence-activated cell sorting (FACS), Fluorophore, Heptamethine Cyanines, IMAGING, Imaging Microscopy, Imaging reagent, MICROSCOPY, near-IR fluorophores, Optical-Guided Surgery

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration

Polymer-Cast Inserts for Cell Histology and Microscopy

Abstract: Three-dimensional (3D) cell cultures systems are important for studying cell biology because they provide in vivo-like microenvironments more physiologically relevant than two-dimensional (2D) culture systems. In 3D culture systems, cells are grown in culture matrixes and turn into spheroids and organoids later processed for downstream analysis...

Published: 4/8/2024 | Inventor(s): Ralph Parchment, Thu Nguyen

Keywords(s): 3D Cell Culture, high-throughput screening, Histology, Histopathology, MICROSCOPY, Organoids, Parchment, Polymer-cast, Spheroids

Category(s): TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials

Enhanced Tissue Clearing Solution, Clearing-Enhanced 3D (Ce3D), Compatible with Advanced Fluorescence Microscopy Imaging

NIH immunologists have created a solution, Clearing-enhanced 3D (Ce3D), that can be used to make entire organs extremely transparent (top right panel). This allows the tissue to be imaged using advanced fluorescence microscopy techniques (bottom panel). Unlike current tissue clearing solutions, the Ce3D tissue clearing solution is robustly compatible...

Published: 7/25/2024 | Inventor(s): Michael Gerner, Weizhe Li, Ronald Germain

Keywords(s): 3D, AA3AXX, Ce3D:, Cellular, Clearing, Epitope, Fluorescence, histo-cytometry, IMAGING, imaging agent, Method, MICROSCOPY, REPORTER, Tissue

Category(s): Collaboration Sought > Collaboration

Microscopy System for Distinguishing Stimulated Emissions as a Means of Increasing Signal

The invention pertains to a system and method for distinguishing stimulated emissions as a means of enhancing signal strength of fluorescent markers in fluorescence microscopy applications. The system is arranged such that an excitation beam (e.g., laser beam) illuminates a sample along some axis exciting the fluorescent markers used in the sample....

Published: 7/25/2024 | Inventor(s): Sanjay Varma, Andrew York

Keywords(s): AC1XXX, AC3XXX, AC4XXX, Distinguishing, Emission, Fluorescence, Increasing, MEANS, MICROSCOPY, Signal, STIMULATED, WMXXXX, XDXXXX, XFXXXX, XGXXXX, YAXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, Application > Software / Apps, Application > Research Materials, Application > Diagnostics, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products

Resolution Enhancement for Line-Scanning Excitation Microscopy

The invention describes a method for improving the spatial resolution of optical microscopes that use line-scanning excitation, such as line-scanning confocal microscopes, line-scanning STED microscopes, or line-scanning light-sheet microscopes. Common elements of the invention include: a) an apparatus for exciting and scanning a line-like excitation...

Published: 7/25/2024 | Inventor(s): Andrew York, John Giannini, Abhishek Kumar, Hari Shroff

Keywords(s): AC1XXX, AC2XXX, AC3XXX, fluorescent, MICROSCOPE, MICROSCOPY, RESOLUTION, XDXXXX, XFXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices, Application > Diagnostics

Resolution Enhancement for Light Sheet Microscopy Systems

The invention pertains to a technique for enhancing the resolution of images in light sheet microscopy by adding additional enhanced depth-of-focus optical arrangements and high numerical aperture objective lenses. The technique employs an arrangement of three objective lenses and a processor for combining captured images. The image composition utilizes...

Published: 7/25/2024 | Inventor(s): Yicong Wu, Sara Abrahamsson, Hari Shroff

Keywords(s): AA2XXX, AC1XXX, AC3XXX, ADXXXX, Light-emitting, Light-scattering, MICROSCOPY, VPXXXX, WIXXXX, XFXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Medical Devices, Application > Research Materials, Application > Software / Apps, TherapeuticArea > Cardiology, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices

Miniature Serial Microtome for Block-Face Imaging

A microtome device is used in a variety of microcopy techniques to remove very thin (e.g., in the tens of nanometers range) portions from the top of a sample between successive images. This technology discloses a design for a microtome device that offers several unique features and advantages over commercially available microtomes. A prototype of the...

Published: 7/25/2024 | Inventor(s): Kevin Briggman

Keywords(s): AC1DXX, AC2XXX, AC3XXX, Block-face, Electron Microscopy, MICROSCOPY, MICROTOME, SCANNING, VEXXXX, VPXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Medical Devices, Application > Non-Medical Devices, TherapeuticArea > Cardiology, TherapeuticArea > Oncology, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Software / Apps, TherapeuticArea > Neurology

Deconvolution Software for Modern Fluorescence Microscopy

This software invention pertains to Joint Richardson-Lucy (RL) deconvolution methods used to combine multiple images of an object into a single image for improving resolution in modern fluorescence microscopy. RL deconvolution merges images with very different point spread functions, such as in multi-view light-sheet microscopes, while preserving the...

Published: 7/25/2024 | Inventor(s): Maria Ingaramo, Andrew York, Hari Shroff, George Patterson

Keywords(s): AC2XXX, AC3XXX, ACXXXX, AD3XXX, ADXXXX, AXXXXX, Deconvolution, fluorescent, Image, IMAGES, IMAGING, Lucy, MICROSCOPY, Microsopy, Richardson, VPXXXX, WIXXXX, XJXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Application > Software / Apps, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology, Application > Research Materials, TherapeuticArea > Ophthalmology

Super-Resolution Fluorescence Enhanced Imaging using Bleaching/Blinking Assisted Localization Microscopy (BALM)

The invention relates to systems and methods for localization microscopy for superresolution imaging of fluorescent molecules. The method utilizes intrinsic bleaching/blinking properties of fluorophores in which superresolution is achieved by capturing successive images and subtracting from each either the subsequent image. The location of a single...

Published: 7/25/2024 | Inventor(s): Bechara Kachar

Keywords(s): AC4XXX, ACXXXX, AXXXXX, BALM, Bleaching/blinking, fluorescent, IMAGING, MICROSCOPY, Superresolution

Category(s): Collaboration Sought > Licensing

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