Search Results - pathology

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Novel Fixative for Improved Biomolecule Quality from Paraffin-Embedded Tissue

Abstract: Tissues samples collected during medical procedures, such as biopsies, are used to diagnose a wide variety of diseases. Before diagnosis, patient samples are typically processed by fixation and paraffin embedding. This fixation/embedding process is used to preserve tissue morphology and histology for subsequent evaluation. Unfortunately, most...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Candice Perry, Joon-Yong Chung, Robert Star

Keywords(s): CULTURE, fixative, Histology, PARAFFIN, PATHOLOGY, Tissue

Category(s): Collaboration Sought > Licensing, Application > Medical Devices, TherapeuticArea > Oncology, Application > Non-Medical Devices

Mitotic Figures Electronic Counting Application for Surgical Pathology

Abstract: Cancer diagnosis depends on the assessment of patient biopsies to determine tumor type, grading, and stage of malignancy. Pathologists visually review specimens and count mitotic figures (MF) in a variety of cancer types to help gauge aggressiveness, guide treatment, and inform patient prognosis. Current technology for recording MF counts...

Published: 5/23/2024 | Inventor(s): Robert Simpson, Munish Puri, Stephen Hewitt

Keywords(s): cell proliferation, COUNTING, ELECTRONIC, MATLAB, Matrix Laboratory, MF, MICROSCOPY, Mitotic Figures, PATHOLOGY, Simpson, SURGICAL

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Oncology

Isotropic Generalized Diffusion Tensor MRI

Abstract: Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring...

Published: 4/8/2024 | Inventor(s): Alexandru Avram, Peter Basser

Keywords(s): ADC, Basser, Central Nervous System, CNS, diffusion, Diffusion Weighted Images, Distribution, DWI, Fetus, High-Order Tensor, Image Analysis, Isotropic Diffusion Tensor Imaging, mADC, Mean Apparent Diffusion Coefficient, MRI Pulse Sequences, PATHOLOGY, Peripheral Nervous System, Placenta, PNS, STROKE, TRACE, Whole-Body

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Software / Apps

Module to Freeze and Store Frozen Tissue

Abstract: Tissue obtained for both clinical and research purposes is routinely frozen, commonly in Optimal Cutting Temperature (OCT), an embedding media, for eventual downstream analysis, commonly including sectioning on a cryostat. Though OCT is the standard compound used for freezing, there is no standard freezing protocol. Thus, current methods of...

Published: 4/8/2024 | Inventor(s): Stephen Hewitt, Jeffrey Hanson, Kristofferson Ylaya, Michael Oshetski

Keywords(s): Biopsy, Biorepository, Cryosectioning, diagnostic, Freezing, Frozen Tissue, PATHOLOGY, Storage

Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, Application > Non-Medical Devices, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Method for High-Throughput Microdissection and Analysis of Biological Samples

Abstract: The National Cancer Institute's Laboratory of Pathology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a method for target-activated microdissection. A variety of techniques have been used to micro-dissect specific cells or cell populations from...

Published: 5/23/2024 | Inventor(s): Michael Emmert-buck, Michael Tangrea, Robert Bonner, Rodrigo Chuaqui, Thomas Pohida

Keywords(s): MICRODISSECTION, PATHOLOGY

Category(s): Application > Non-Medical Devices, Application > Medical Devices, Collaboration Sought > Licensing, TherapeuticArea > Oncology